Amphetamine Neurotoxicity and Tolerance Reduction/Prevention II

[campers]

Been doing some digging through some obscure NOS/transcriptional changes lately, and I'm slowly finding why several studies have identified continued cell death for up to 2 weeks in rat models. What are possible implications of that? Well it would suggest that longer post loading for recreational users might be a good idea.

Could you post some links to the papers? I'd be interested to have a read.

I just noticed a couple of papers about modafinil protecting against meth toxicity, interesting.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464292/
http://www.ncbi.nlm.nih.gov/pubmed/21590747/
http://www.ncbi.nlm.nih.gov/pubmed/1347270 (this one is MPTP induced DA neurotoxicity, not meth)

 

[Epsilon Alpha]

Could you expand on this a bit? I have no idea what this means.

As cell death seems to happen over a longer period than one would expect in animal studies there is reason to try and maintain levels of antioxidants post usage, and possibly let them build up in your system prior to dosing.

Gonna close this at 300 replies, see you in Part III!