Personally I have read all the threads on various forums saying that Nucynta is weak, or Nucynta doesn't have much of a euphoric effect. I disagree with every single one of these posts. The one thing I would note is that for me it takes a week or so to start feeling the full effects of the drug. I moved from NY to NC a few months ago. In NY I was receiving Nucynta 100mg 4x a day for Back Pain(Herniated L5-S1). After I moved to NC I had trouble finding a Pain clinic that would work with my coverage from NY. I went through withdrawal from Nucynta which was terrible and I described in a previous post. When I first got into a clinic down here they started me on half my old Nucynta dose 50mg 4x a day which pretty much did nothing for me but I took it to let it build up in my system for the month.
This month after the abnormal results of my disco-graph came back I talked with my doctor about getting back to my normal dose of Nucynta and she said that they don't prescribe IR Nucynta over 300mg, and thus the Nucynta ER was born. She said she would work me back up to 400-500mg over the next couple months starting me on Nucynta ER 100mg 2x a day and Nucynta IR 50mg 2x a day. I have to say I wake up less "hungover" taking an ER before bed over the IR, probably because it stretches out the medication a bit more but the one thing I have been finding out is that the ER seems very unpredictable when it comes to potency. There will be times when I am almost not sure I took my ER, and others where out of nowhere I am ready to nod out. I do get a pleasant euphoria from the Nucynta, the kind that makes you just want to kick back and close your eyes, it makes me VERY sociable and if I am kept busy keeps my energy up... kinda of like an upper and downer at the same time.
I'm still not feeling the level of relief I was feeling when I was on the 100mg 4x a day except the times I take the 50mg on top of my ER's. At my next appointment I am going to ask for my Nucynta ER to go up to 150mg 2x a day and still get the 50mg IR 3x a day as needed. Below I am going to give my *rating* of Nucynta compared to other drugs I have taken.
I have taken hydrocodone, oxycodone, Opana IR & ER, Morphine Sulfate SR, Nucynta IR & ER
talking pain relief Best(1) to Worst(5):
1. Opana IR/ER
2. Nucynta IR/ER
4. Morphine SR
talking euphoria Best(1) to Worst(5):
2. Opana IR/ER
5. Morphine SR
Comparing doses mg for mg in strength here is my personal experience/opinion
now these are just my personal experiences...it seems everyone reacts a bit different to certain medications. I wish my stomach could deal with the Opana as all around I think that was the best drug that dealt with my pain, but Nucynta is a close second at the right dose.