At one time I was prescribed both Ambien & Hydrocodone from the same doctor. I forget what mg the Ambien was, but it was 1 at night for sleep. The longer I took them I ended up taking more a dose at 1 1/2 - 2 to get to sleep. The Hydrocodone was 1-2 a dose and was 5/500mg. Depending on pain, a lot of times I'd end up taking 3-4 Hydrocodone. (A couple of times he changed the Hydrocodone to either Percocet or Norco.)
As far as mixing during the day, I never did...I didn't see the point in it as it didn't do anything to make the Hydrocodone any better. One thing with the Hydrocodone other than for pain, it acted like a stimulant, so I didn't want to kill that during the day.
So anyway, it was safe "FOR ME" to mix them and it was also prescribed...but that doesn't mean it is safe for you!!! No one here can tell you that! Even a doctor knowing you can't ever be 100% sure what drugs are safe for you until after you've taken them.
Leaping Gnome