Morninggloryseed
Bluelight Crew
- Joined
- Aug 22, 2000
- Messages
- 13,773
I don't understand how you can equate getting 8 hours of sleep with having mu-agonism, or even stronger mu-agonism than ketamine. There are some studies out there that show ketamine works as a therapeutic tool for RLS and it clearly doesn't have much if any noticeable opioid effects. It's well known that NMDA-antagonists like ketamine decrease the required dose of mu-opioid agonists for equal analgesic properties as a higher dose of the opioid alone, but that doesn't mean this is the mu agonism at work. Some of the best opioid drugs used for severe RLS have NMDA-antagonist properties (tramadol, methadone, levorphanol, propoxyphene), giving speculative evidence that the NMDA-antagonism may be a pharmacological benefit to the opioid for treatment, or that nmda-antagonism alone like with ketamine could be enough to treat RLS symptoms. My neurologist has told me that propoxyphene was one of the better RLS opioid drugs when he could script it (better than non-nmda-antagonist opioids like hydrocodone), and being that propoxyphene is a shitty opioid, there must be once again some evidence that even having NMDA-antagonism alone can be enough to help produce a better nights sleep.
I really don't see any proof at all the MXE has any relevant mu-opioid agonism that would produce anything discernible to a human that could be called mu-opioid effects/opiate like pharmacodynamics. Seems like people just want to fantasize about combining the wonders of mu opioid agonism and nmda-antagonism dissociative into one drug. The mind is a powerful thing and can create something you feel validates a rationalization to assume so.
Clearly I made my statement based on my own experience, and nothing else. What is with people on this forum, any observation is chewed up if it doesnt square with what they believe! You did nothing more than state your observations and circumstantial evidence. You have not a single fact either.
If I had tried to make a statement and passed it off as research I could see a beat down being warranted but in this case I was very clear that my statement is my own observation and nothing more. Now go, and take your ugly mother with you.
I have no fantasy or agenda. I have made it very clear that I do not enjoy the effects of MXE in other posts. I simply have shared my own observations, which were unexpected, but clearly irrelevant in your lofty opinion.