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Opioids Ace/Ibuprofen Plugging Q.

infectedmushroom

Bluelighter
Joined
Mar 14, 2007
Messages
1,371
Would plugging codeine with ibuprofen (I know the bio orally is higher) be safe? I remember reading somewhere that anal absorption of ace/paracetamol is inneffective as the drug is very poorly absorbed into the anal wall.

What about ibuprofen? I'm just feeling like changing things up a bit, and am feeling lazy (cbf the CWE! =D)

Thanks.
 
For gods sake please dont do this. just take the pills orally. besides i am pretty sure codeine is a prodrug, so you would need to take it orally for your liver to metabolize it on 1st pass. So yeah, just stick to taking them orally.
 
^ This dude is right codeine is a pro drug so take it orally. Who wants tylonel up the bum anyway. :)
 
APAP and ibuprofen diffuse quite well across the rectum, the mfg's even sell Tylenol/Panadol suppositories. Codeine rectally is a waste of time as others have pointed out, however.
 
this will BURN. In fact i think its the main contributing factor to the hemmorhoid I had several months ago. DO NOT DO THIS!!! unless you want a hemorrhoid or chemical burn feeling in your anus. (this was with 100 mg ibuprofen in the form of vicoprofen).
 
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