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Thread: Ace/Ibuprofen Plugging Q.

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    Ace/Ibuprofen Plugging Q. 
    #1
    Would plugging codeine with ibuprofen (I know the bio orally is higher) be safe? I remember reading somewhere that anal absorption of ace/paracetamol is inneffective as the drug is very poorly absorbed into the anal wall.

    What about ibuprofen? I'm just feeling like changing things up a bit, and am feeling lazy (cbf the CWE! )

    Thanks.
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    #2
    Bluelighter 'medicine cabinet''s Avatar
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    For gods sake please dont do this. just take the pills orally. besides i am pretty sure codeine is a prodrug, so you would need to take it orally for your liver to metabolize it on 1st pass. So yeah, just stick to taking them orally.
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    #3
    Bluelighter
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    ^ This dude is right codeine is a pro drug so take it orally. Who wants tylonel up the bum anyway.
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    #4
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    sekio's Avatar
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    APAP and ibuprofen diffuse quite well across the rectum, the mfg's even sell Tylenol/Panadol suppositories. Codeine rectally is a waste of time as others have pointed out, however.
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    #5
    Bluelighter
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    this will BURN. In fact i think its the main contributing factor to the hemmorhoid I had several months ago. DO NOT DO THIS!!! unless you want a hemorrhoid or chemical burn feeling in your anus. (this was with 100 mg ibuprofen in the form of vicoprofen).
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    #6
    Haha...all right I get your message ...oral it remains
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