This was actually a comparison between 3 generics, but since it is not allowed in BDD rules, I'll drop the issue except to address generic formulations comparisons of all drugs.
I cannot agree with you, though. The FDA has high, low and mean titration value for any given drug. Now as long as the drug has a 'mean' value that fits into their requirement gradient, they are allowed to produce it and label it as 'x' strenght. But, as I stated in my earlier post, the serum concentration mean value in question is .8ng lower *and* 6 hours slower to reach max. This would have a NOTABLE effect for the wearer, would it not?
The graph of serum concentration high-vs-low in the product insert varied from .5 to 3 supporting this, so in fairness for any given patch on any given person there can be a wide range of analgesia. Even skin prep can effect drug transfer on the same wearer.
Knowing this along with the fact that it has a membrane between the polymer matrix and the skin whereas others skip this membrane and allow the polymer matrix to deliver the drug, wouldn't it be safe to assume that, by design it is a slower releasing patch, therefore causing me more achiness, less analgesia and making me want to choke the life out of my pharmacy. After changing patches, it took about 12 hours before I started feeling the difference.
Now can we sorta get back on topic since the mods so graciously allowed this thread to remain on how to extract a mallinckrodt patch.
Neepanoid