I tried searching the forums for this but I couldn't find an answer I was satisfied with.
Basically, I took 20mg of methadone at 10 am today and I was planning on going out to the club and taking 2 doses of MDMA at 10 pm tonight, 12 hours later. I've heard a lot of things about how methadone can have dangerous interactions with other drugs, but I havn't heard anything about it's interaction of MDMA. I have taken suboxone with MDMA and didn't feel any negative reaction whatsoever. I'm also curious if the methadone well still even really be effecting me by 10pm tonight.
For reference, I have a decent opiate tolerance (it takes me 40mg of OC to really feel it, I've only taken methadone a few times though) and I have a decent MDMA tolerance (I use it about 1-2 times a month). I'm also positive that the stuff I have isn't cut with other substances.