For me, I've always had fun whether drugs were involved or not. I take good care of myself, eat really healthy (lots of dark green leafys, ginger, hemp seed, flax seed, etc.) exercise regularly and meditate.
IMO bad diet and exercise will affect you more than any pill will. It causes more premature deaths, illness, disease, etc. than any drug ever will. And, yet, nobody seems too interested in harm reduction from the dangerous American diet or sedentary lifestyle. That's where we need harm reduction the most.