I have been interested in this for quite some time after having my own personal experiences with PR's, but have never found an explanation to how drugs go wrong.
For some examples what are the possible pharmological actions behind the following:
Benzos causing excitability, insomnia, rage, convulsions, and rage;
Sedative antihistamines causing hyperactivity and insomnia;
Opiates causing hyperactivity and insomnia;
and other "sedative" drugs such as trazodone, amitryptaline, gabapentin, and phenobarbital causing similar reactions.
So how or why do these types of reactions happen? In addition to the sedatives mentioned above I'm interested in any other PR info on any other drugs anyone might have. Thanks.