fencamfamine
Bluelighter
- Joined
- Feb 26, 2011
- Messages
- 151
Some months ago I was lucky enough to sample 60mg of fencamfamine - it is without a doubt the best stimulant I have ever tried. I have read that it has opioid activity & this seemed apparent in the euphoria and relaxed (for a stimulant!) feel.
I decided to have a look at the SAR to see what else is out there with similar activity. Tilidine, which is a prodrug (nortilidine is the active principal) certainly sounds similar. More opioid activity but there is certainly DRI activity. I see it has become a big problem in Germany - much media hype but some truth.
Cypenamine, with N-alkylation looks like it would also have fencamfamine-like activity but to really push up the opioid activity, one would assume an ester at the alpha position would be important.
It turns out that this has been researched. The propanoate ester of 2β-methylamino-1-phenylcyclopentanol is an opioid analgesic with an activity slightly higher than morphine & DRI activity around 50% of methamphetamine.
From the paper I read, it is apparent that the ester could be added to the fencamfamine skeleton just as easily but my question is, does that second ring perform an important function? I suspect that the cyclopentane/cyclohexene performs an important function on confirmation.
Many thanks for your help in this.
-F-
I decided to have a look at the SAR to see what else is out there with similar activity. Tilidine, which is a prodrug (nortilidine is the active principal) certainly sounds similar. More opioid activity but there is certainly DRI activity. I see it has become a big problem in Germany - much media hype but some truth.
Cypenamine, with N-alkylation looks like it would also have fencamfamine-like activity but to really push up the opioid activity, one would assume an ester at the alpha position would be important.
It turns out that this has been researched. The propanoate ester of 2β-methylamino-1-phenylcyclopentanol is an opioid analgesic with an activity slightly higher than morphine & DRI activity around 50% of methamphetamine.
From the paper I read, it is apparent that the ester could be added to the fencamfamine skeleton just as easily but my question is, does that second ring perform an important function? I suspect that the cyclopentane/cyclohexene performs an important function on confirmation.
Many thanks for your help in this.
-F-
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