Sorry to dig up an old thread but I'm glad I'm not alone here. I use kratom to relieve my GAD sometimes so I'm not always using benzos. But I'm also scripted Vyvanse for ADHD which causes some minor anxiety. I've had the script for about a year now so I have tolerance and I never abuse it. Mixing benzos with the Vyvanse usually kills most of the anxiety without dulling the stim too much if the dose is right, so I wanted to try the same with kratom. I'd already mixed weak opiates like codeine with the Vyv but all I got was a stomach ache. The kratom feels stronger than codeine to me so I was hoping it'd do the trick. It's red Bali kratom too so it's quite a sedating strain, and it's powdered leaf, not an extract or headshop rubbish. I previously smoked weed on this kratom without any issues aside from the usual mild weed paranoia.
Long story short, in the morning I took my usual 30mg Vyvanse dose and about 2.5 grams of kratom. I've been using kratom daily for a week at this point (but previously skipping the Vyvanse) so I was comfortable with it and have a little tolerance.
I had a good day on this combo and it wasn't until about six hours later as the Vyvanse was wearing off things turned bad. Suddenly I feel my heart beating out my chest. I figure it's the regular comedown so I took a little more kratom, only around 500mg, to calm me a little more.
But about 10-20 minutes later I was having a full blown panic attack. Not just a few panic attack symptoms, I mean I was so hot I was sweating, my heart rate went through the roof, I was breathing fast, I was trembling, I felt impending doom like I was about to die, I kept feeling sick, I had derealisation, and I felt so lightheaded and dizzy it was like I was about to faint.
It was fucking horrible, unmistakably a real panic attack no question. I took benzos and laid down for a few hours and slowly it got better. But it seriously took hours to go away fully even with benzos.
Once it was over I started feeling the positive effects of kratom again, it was still in my system working but the Vyv had worn off by that point. So I can only guess the two interacted very badly.
Lesson learned the painful way: do not mix amphetamine and kratom if you have anxiety. Kratom does not take the edge off stims like benzos do.