Weight: approximately 200lbs, dosage: 350ug. It felt similar to around 100ug of acid, prefer all my acid trips to be around 175ug, so next time will use around 450 to 500ug of HPBCD-complexed 25i-nbome via the same upper gum buccal route. Have previous experience (years ago) with HPBCD-complexed testosterone, and also used various cyclodextrin-based pro-hormones such as Ergopharm's patented "cyclo-diol" (creator elite chemist Patrick Arnold), highly effective. These were widely available before the Pro-hormone ban which took place during Bush years. Testosterone & pro-hormones are all hydrophobic (water-fearing) drugs like 25i-nbome.
Several weeks earlier, 100mg of 25i-nbome had been added to 100ml of 95% etoh (drinkable alcohol) and also added 1000mg (1g) of HPBCD (hydroxy-propyl-beta-cyclodextrin) powder as well, allowed it all to magnetically stir for 24 hours, even though 8 hours would have been fine. Stored away in freezer. I would recommend to future researchers to simply add 100mg of 25i-nbome to 50ml of 95% etoh (instead of 100ml of 95% etoh) for a final drug ratio of 200ug per each 0.100ml on the insulin syringe. If so desired, 1000mg of HPBCD could be added as well, then stir it all for around 8 hours, though I let it stir for 24 hours.
Tried an entirely brand new
BUCCAL experiment. Most successful ROA to date. I would venture to say that HPBCD-complexed 25i-nbome does indeed achieve 95% absorption when left on the upper buccal gum surface in 20 minutes.
Got fed up with nas*cort spray bottles breaking after only a couple experiments, not being able to get all the solution out via spray pumps, the etoh nasal burn, etc, etc.
1) a blotter was prepared from a 2" long x 3/8" wide piece of #103 filter paper was cut from a #103 filter disc.
3) Approximately 5 mg of HPBCD (hydroxy-propyl-beta-cyclodextrin) powder was put on the edge of a card and lightly "sprinkled" back and forth onto the 2" long filter paper blotter that was held suspended horizontally by a clothespin.
4) then 0.350ml of the etoh solution (350ug of drug) was sucked up via insulin syringe and deposited back and forth on top the cyclodextrin powder that adhered to the 2" long filter paper blotter, it was then allowed to dry for 15 minutes as described below.
5) Then placed the "sticky/glossy" blotter in front of a Holmes ac powdered fan heater and the strip was completely dry (except for the sticky HPBCD clear resin on the surface) in 15 minutes.
7) Placed on upper gum (like you would similar to a crest whitening strip) and did not taste hardly any etoh whatsoever, there was 0% burn, indicating that nearly all of the etoh did indeed evaporate leaving only sticky sugary HPBCD complexed drug on the blotter (as would be expected).
If HPBCD does indeed cause
95% sublingual absorption of hydrophic drugs in 20 minutes (pitha, joseph. study on HPBCD complexed testosterone) then I should feel the 350ug of drug quite well.
I have read many reports of HPBCD powder in the past working simply by overlaying the drug & a bit of water over the powder and allowing it to "sit and complex" over a course of less than an hour (old bodybuilding forums). In this case, I overlayed the etoh dissolved drug solution onto the cyclodextrin powder which simply laid on top the filter blotter paper.
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it worked.
6:20 applied buccal strip.
7:50 it hit with full force, full effects felt.
This is my best experience (and best ROA, route of administration) with this molecule to date, tripped much harder than last time (the nasal experiment)..
Have noticed with the iodo-molecule, it takes 1.5 hour for it to hit full-force, that is when it starts working very well. pupils larger at 1.5 hours, the HPBCD-complexed 350ug of etoh dissolved drug applied buccaly for 20 minutes works excellent. Felt the deep shining empathogenic qualities of the 25i-nbome for the entire trip, making it quite magical. This along with the normal visual, audial, mental effects. Music sounded amazing as well.
Tripped way harder than last time due to lowered tolerance. Will never go back to the nasal method, the HPBCD-complexed molecule bucally applied works with the same potency as nasal. FYI: Have seen hydroxy-propyl beta cyclodextrin powder still available on auction sites now and then, but other than that it is hard to find.
The Joseph Pitha study showed that when testosterone was complexed with hydroxy-propyl-beta-cyclodextrin, that 95% absorption was achieved in 20 minutes via the sublingual route, whereas normally hydrophobic testosterone is absorbed less than around 40% normally via sublingual route.
How HPBCD (hydroxy-propyl-beta-cyclodextrin) works to significantly improve buccal/sublingual
absorption:
http://www.pharmainfo.net/reviews/cy...systems-update
http://www.aapspharmscitech.org/view.asp?art=pt060243
Think of it as like a "molecular condom" that fits the drug so that it can be delivered across sublingual/buccal membranes with significantly improved efficiency.
Out of all the RC's to make it down the pipeline over the many years, this one is a shining star. It would be nice to perhaps add some 5-ht1a agonism in the future, but that could be done with possible low-dose combination of 4-ho-mipt for example, as that compound is mind-manifesting, deep intellectually. Other than that, 25i has all the other fine attributes of lucy, including the deep empathogenic qualities for the entire duration of the experience, increased music appreciation, etc.
There are actually a couple places (outside of auction sites ) that directly have Hydroxypropyl Beta Cyclodextrin. In any case, there are hundreds of research papers on the science of HPBCD, "Trappsol" and other fancy sounding brand names are currently used for the stuff these days it seems.