I came across a thread about someone wanting to discontinue their Celexa because it had fluoride in it. which led me to look it up and find that most common SSRI's nowdays have fluoride in them. I thought ingesting this was dangerous, hence why we are not supposed to swallow toothpaste. Can anyone tell me why fluoride is in most common SSRIs today? including celexa, paxil, and prozac? wouldnt the fluoride be ingested with the pill and wouldnt that be bad for ones body? does anyone have and answer? I found this on a website
"Selective serotonin re-uptake inhibitor (SSRI) drugs are commonly prescribed to treat depression.
These drugs incorporate fluorine into their chemical structure.
Brand Name Generic Name
Celexa ‣ citalopram
Lexapro ‣ escitalopram oxalate
Luvox ‣ fluvoxamine maleate
Paxil ‣ paroxetine
Prozac ‣ fluoxetine
Zoloft ‣ sertraline (chlorine instead of fluorine)
The drugs are designed to block metabolism of the neurotransmitter serotonin. The result is increased serotonin.
It appears this may not be a good approach. Excess of a neurotransmitter makes it excitotoxic.
This is significant because depression is an excitotoxic condition -- it is the result of excess glutamate activation in the frontal cortex of the brain (basis here and here). Manipulating the level of serotonin does not address the underlying problem of excess glutamate. Instead it simply adds burden to the degenerative condition already underway. Recent research indicates that genetic variability in glutamate activity can make a significant number of people more sensitive to SSRI effects, including a much higher likelihood of expressing suicidal thoughts.
Serotonin receptors exist throughout the body. Altering the level of serotonin affects the entire body, not just the brain. Elevated serotonin is associated with
Altered REM sleep behavior
Autism spectrum disorders
Mood disorders (wild mood swings)
Organic brain disease
Several things happen as the SSRI forces a constant excitotoxic state -- serotonin receptors die off, serotonin levels become depleted, and a cascade of metabolic disruption takes place. The person becomes acutely worse. Additional conditions SSRI's have been shown to directly trigger include
Congestive heart failure
Also, any SSRI crosses the placenta and exposes the fetus to its effects.
There are hundreds of high-profile cases of murders, suicides, school shootings, incidents of workplace violence, road rage and other events -- all tied to the use of prescription SSRI drugs. "
Source ( http://www.sailhome.org/Concerns/Bod.../Fluoride.html )