No, it doesn't address the need for air at all as far as I can tell.
Something I forgot to mention is that the reaction would be quite hindered by the other groups, this is something which disfavours it.
I couldn't see anywhere air (oxygen) might come in, oxidation of the MD ring doesn't really seem viable, not only would it be very slow, if at all possible with elemental oxygen but I can't see much being put there without rendering it inactive. I definitely don't see oxygen doing anything anywhere else.
Perhaps 2 OH groups replacing the MD to create something a little more like... [aha] dopamine?
Seems like this, or a variation of it might have potential, after all, we're not trying to stimulate serotonin so much here, MDPV might benefit from this increased relation to dopamine.
It needn't be exactly that, perhaps a methoxy and hydroxy, or similar, but this could have potential. I will ponder on the potential of this and see if I think there might be a mechanism.
We have a weak base, in water, and air exposure does seem significant. hmmm