In my clinic they have a sign of a few drugs that increase the methadone levels in the body, and a few that lower the methadone levels. Alcohol is stated as one that lowers the levels. I have spoke to people there who have said they notice they feel a little dope sick either while drinking or after. It could be that this sign just put the idea in their head...i dont know though i must admit i have noticed this sometimes as well. I haven't been able to find any information about this except for this paper posted up on the wall. Does anyone have any further info?