http://www.clevelandclinicmeded.com/medicalpubs/pharmacy/septoct2005/pregabalin.htm
This is an excellent discription of how pregabalin/Lyrica works and raises some questions.
One of the main things I was looking at was according to The Cleveland Clinic, 50 mg pregabalin equals 300 mg of gabapentin.
50 mg pregabalin = 300 mg gabapentin.
In the last 1.5 hours , 900 mg of pregabalin was ingested on an empty stomach.
So does that equate to 5.4 grams of
gabapentin?
I am feeling pretty nice atm.
This also makes me give more thought to stacking Lyrica ala Gabapentin, as in
75 mg - 150 mg Pregabalin every 1-1.5 hrs.
This is completely subjective, but when I stack Pregabalin @ 150 mg, every 1-1.5 hrs, I feel the peak lasts longer.
This dose was taken after a two week clear out of pregabalin.
Thoughts?
Speed King, I'm totally into the idea that you've presented regarding the stacking of Pregabalin (Lyrica). Those of us who have experience with Gabapentinoids know all about the nature of Gabapentin (Neurontin) and how it follows a strange bioavailability pattern. You can only absorb so much Gabapentin. In my experience there is a definitive limit. I have ingested literally dozens of grams of Gabapentin with high tolerance and felt basically nothing. So, if you have a very high tolerance to Pregabalin or another Gabapentinoid, it could actually be impossible to experience any effect whatsoever. Too much of my life has been dedicated to understanding this strange drug.
So, I guess what I'm saying, is that, yea, you have ingested that equivalent dosage, but at the same time that dosage would probably be impossible to be fully absorbed. I would like to note that when I take Pregabalin in a very high dose, with no tolerance, I can experience severe Myoclonus (jerking movements). If I ingest a small amount, say, 150mg as you've said, I can then dose as high as I want without experiencing any Myoclonus and furthermore, get this, if I do take enough to initiate these Myoclonic movements, if I take more Pregabalin, even the next day or the day after, I will continue to experience Myoclonus until the Pregabalin has completely cleared and I try again a few days later. It's such a goddamn mystery.
I would be very interested in hearing from others who have experienced this, as it appears to be a fairly rare side effect. Most prescribers I've talked to are unaware that this is a possible side-effect. Also, and this one can really fuck you over good, they seem to be essentially unaware that there is a severe (or any) withdrawal syndrome from Gabapentinoids, when in reality, the withdrawal appears to be akin to Benzodiazepine withdrawal, in that it can make you totally non-functional and turn your life into a living nightmare. I'm sure you've all read stories about Phenibut (OTC Supplement) and the horror stories.
I believe, actually, that the Phenibut Diaries, as it were, are some of the best resources for predicting the outcome of dependence, tolerance and withdrawal from the other Gabapentinoids. Why? Phenibut is pretty cheap and can be bought over the internet by the pound. This allows us to see what would happen if one had a truly limitless supply of these drugs. The stories people tell sound downright nightmarish. Gabapentin is self-limiting, as we have said but who has an endless supply of Pregabalin? Not most people. If we examine peoples' experience with Phenibut, I think we can draw a reasonable comparison and predict how Pregabalin might work.
Check this one out as a point of reference, but a simple Google search turns up a litany of horror stories concerning the substance. Even the people who sell it provide a guide to withdrawal.
http://www.bluelight.org/vb/threads/721313-Phenibut-Withdrawal
Thoughts?
