I've smoked pot for many years now, throughout that time I have tried several other drugs on various occasions. Throughout that time I have found an interesting trend, basically it comes down to the fact that when I eat coke, molly/Ecstasy, pot, or opiates (such as Vicodin, or Oxycontin) I appear to gain no effects from any of the drugs listed above. However, I get perfectly high whenever I smoke pot as well as if I ingest mushrooms, LSD, or alcohol. And I can assure you that (almost) all of the drugs I took were real and in high enough dosage that I should have felt something.
I had originally thought that maybe I just wasn't able to absorb very well with my digestive tract, but that idea falls part when you consider the drugs that work for me when they are ingested. The only plausible explanation i can think of is that my digestive tract produces an enzyme which breaks down dopamine like molecules as coke, opiates, and THC all fall under this category where as psylopsybe and LSD are both serotonin based molecules while alcohol is something else entirely.
I would greatly appreciate any further insight as to my apparent condition.