well aren't you just full of terrible information?
first off, the pill doesn't have more than stated, if its extended release, and its 15mg, then its only got 15mg in the pill, not a higher dose.
Perhaps I wasn't clear. I meant that it takes a higher dose of extended release morphine than instant release to achieve the same effects.
AND THEN, nasal use of morphine has a lower BA than oral for morphine. so theres not conflicting information on that. you just have bad information.
Well,
this abstract, done on rats btw, states "At both 5 and 15 min after administration, brain hemisphere morphine concentrations after nasal administration were similar to those after i.v. administration of the same dose, despite lower plasma concentrations after nasal administration."
but, other studies, such as
this one, state that intra-nasal morphine is only 10% effective compared to I.V. when administered to sheep. The same article also quotes studies on rats that put intra-nasal morphine at 60% and 86% of I.V.
This abstract, done on humans, states " Overall, i.n. morphine 15 mg presented an efficacy profile similar to i.v. morphine 7.5 mg."
So, you can see there is in fact conflicting information. I have yet to find a study that explicitly compares the effectiveness of oral, nasal, rectal and IV morphine in humans. If you know of one, please share.
also, you will not get a buzz off of 15mg of morphine unless you do it IV, and I don't recommend. you're better up passing up on the pill and keeping your money, or if you already bought it or whatever, just hold onto it. folks, 15mg of morphine is equal to about 5mg of hydrocodone.
Some people claim to get high on 15mg. I'll agree that the majority people wouldn't feel it. but as with all drugs, some people are naturally sensitive to it.