RH-34, thats the bugger.I can't help but wonder, if given we know that RH-34 is a moderately strong partial agonist at 5HT2a, even with the N-BOMe sidechain, being a partial agonist that bodes a lot better for safety than the NBOMe phenethylamine/amphetamine compounds and their iffy track records and steep as hell, unpredictable dose-response curve; if this couldn't give us another backbone for design of a whole new series of psychedelics. 'Quinazolinediones I have known and loved'?
We have tryptamine, ergoloid, substituted phenethylamine and amphetamine, plus the benzothiophene homologs of tryptamines are also active (I'd be curious to see if replacing the indolic nitrogen with an oxygen atom would give active compounds also, since replacing nitrogen with sulfur in DMT apparently gives an active compound. Or perhaps, with the more potent orally active compounds, or very potent smoked compounds, replacing sulfur with selenium. Te is out of course, because even the most miniscule absorption of tellurium into the human body causes 'tellurium breath', a most persistent and to both the afflicted individual and those around them, highly distressing stench emitted from any and every bodily mode of excreting either gas or fluid or solids. It's reputed to be so intolerably foul that not only will it make any afflicted individual a social pariah until it eventually wears off, that some have apparently comitted suicide because the disgusting reek was so foul they just couldn't tolerate it, nor the effects of its making them a pariah to anything living (apparently one can even tell which books an afflicted person has read because the traces of volatile tellurium compounds in the sweat and oils covering the tips of their fingers where they have turned pages leave revolting-smelling traces behind )
I've had that happen as a consequence of ingesting a sulfur compound over a prolonged period of time, a sedative-hypnotic, and over time, at the high end recreational dosage being taken, over a good few days, what at therapeutic or a few recreational doses is undetectable, built up until the most heinous, stygian, sulfurous, vomit-making stench was coming out of sweat, saliva, shit, piss, tear fluid, even nasal fluid. Thats right, it came out IN my nose, and coming out in my saliva, I could TASTE it, for over a week I had to remain in the same set of clothes, and endure this hideously potent, far-carrying stink following me everyhere, and which was so powerful that people quite literally would turn, cross the road, turn round and RUN in the opposing direction once I got to within about 100 meters of them. The clothes, had to stay in what I was wearing when it happened, because bar my shoes which could survive being dumped in hypochlorite bleach for a few hours, the fabric clothing however was so tainted that it could never be worn again, and had to be wrapped in a plastic garbage sack, double-bagged in same, taken out to the middle of nowhere, soaked in flammable hydrocarbons and set ablaze to destroy them completely. Even ruined a leather belt beyond any hope of rehabilitation. There is a general rule that the oxygenated compound usually doesn't smell foul, the sulfurous version smells nasty, the selenium version smells MUCH worse, and the tellurium analog smells so intolerably revolting that nobody wants anything to do with it.)
MK-801 is one I'd love to try, along with a fair few non/uncompetitive antagonists of NMDA receptors.
Xenon...I'd be interested in trying it, I actually know somewhere I could buy a small portable cylinder of very pure xenon gas, about the same size as portable argon welding gas cylinders, although IIRC the capacity is higher than these. Should take the same regulator as goes on the portable argon and CO2 tanks I use for providing various chemical reactions with inert atmospheres I imagine. Very expensive though, about 300 euros a tank of ultrapure xenon. Suppose I could use the rest for some interesting xenon chemistry, since it forms compounds a lot more easily than do most noble gases, could provide me with some useful fluorinating agents. Xe is expensive since it is the rarest of noble gases, not counting radon (which is radioactive and as such not something one wants to inhale) and oganesson, a wholly synthetic superheavy element made in particle accelerators, no stable isotopes, highly radioactive, only a single-digit number of atoms have ever been made)
I really can't wait to try those 3-brominated difluoromescaline and 3-bromo-difluoro-TMA analogs. Brand new territory to explore, and even if it does go south and either the phenethylamine or amphetamine or both prove inactive, then the bromine can always be swapped out for a methoxy group with NaOMe, to give difluoromescaline and the corresponding TMA.
So one way or the other, win win. I'm hoping the target compounds are active of course, in which case a smaller quantity of difluoromescaline/TMA will be prepared. Either way,it'll be interesting.
5-MeO-MET and EPT look promising.
