J Pharmacol Sci. 2007 Feb;103(2):201-6. Epub 2007 Feb 8.
Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats.
Tokunaga S, Takeda Y, Shinomiya K, Hirase M, Kamei C.
Department of Medicinal Pharmacology, Okayama University Graduate School of
Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka 1-1-1, Okayama
The present study was undertaken to investigate the effects of some
H(1)-antagonists on the sleep-wake cycle in sleep-disturbed rats in comparison
with those of nitrazepam. Electrodes were chronically implanted into the frontal
cortex and the dorsal neck muscle of rats for the electroencephalogram (EEG) and
electromyogram (EMG), respectively. EEG and EMG were recorded with an
electroencephalograph. SleepSign ver. 2.0 was used for EEG and EMG analysis. The
total times of waking, non-rapid eye movement (non-REM), and rapid eye movement
(REM) sleep were measured from 10:00 to 16:00. Nitrazepam showed a significant
decrease in sleep latency, total waking time, and delta activity and an increase
in the total non-REM sleep time. A significant decrease in the sleep latency was
observed with diphenhydramine, chlorpheniramine, and cyproheptadine.
Cyproheptadine also caused a significant decrease in the total waking time and
increases in total non-REM sleep time, REM sleep time, slow wave sleep, and delta
, although no remarkable effects were observed with diphenhydramine and
chlorpheniramine. In conclusion, cyproheptadine can be useful as a hypnotic,
having not only sleep inducing-effects, but also sleep quantity- and
PMID: 17287588 [PubMed - indexed for MEDLINE]