Gormur
Bluelighter
- Joined
- Jan 20, 2009
- Messages
- 3,331
Hopefully this won't be moved to BDD as i often find specific questions of mine left unanswered there...
So far i know that lorazepam is partially soluble in alcohol & lipid soluble, tho to a small degree. I don't know the B/A. I suppose dosing on an empty stomach helps speed up the process & deter any hindrance to the absorption process
I drink 20ml WGFJ 30 minutes pre-dose on an empty stomach. After i take the dose (sublingually), i lie there somewhat relaxed but unable to sleep. I know it takes a while to absorb this way, due to the low lipid solubility - which also makes me wonder if by using this MOA i'm wasting much of the active drug
I thought about plugging, but i suppose we're dealing with the same issue here - lipid solubility
Please note i have zero tolerance to benzos atm; altho i've been on my fair share over the years & may have a natural tolerance above what is typical
My script is .5mg ativan - yes it's low. I had to take 2.5mg last night to voluntarily fall asleep - altho i slept well -- altho I do not want to take that much if i can take less without wasting anything & still be effective
Any suggestions on MOA would be greatly appreciated.
I'm open to IVing if it's relatively safe & has a higher B/A
-G
I found this, regarding intranasal administration of lorazepam:
http://jcp.sagepub.com/cgi/content/abstract/41/11/1225
according to this, nasal admin has a high bioavailability- around 77%
So far i know that lorazepam is partially soluble in alcohol & lipid soluble, tho to a small degree. I don't know the B/A. I suppose dosing on an empty stomach helps speed up the process & deter any hindrance to the absorption process
I drink 20ml WGFJ 30 minutes pre-dose on an empty stomach. After i take the dose (sublingually), i lie there somewhat relaxed but unable to sleep. I know it takes a while to absorb this way, due to the low lipid solubility - which also makes me wonder if by using this MOA i'm wasting much of the active drug
I thought about plugging, but i suppose we're dealing with the same issue here - lipid solubility
Please note i have zero tolerance to benzos atm; altho i've been on my fair share over the years & may have a natural tolerance above what is typical
My script is .5mg ativan - yes it's low. I had to take 2.5mg last night to voluntarily fall asleep - altho i slept well -- altho I do not want to take that much if i can take less without wasting anything & still be effective
Any suggestions on MOA would be greatly appreciated.
I'm open to IVing if it's relatively safe & has a higher B/A
-G
I found this, regarding intranasal administration of lorazepam:
http://jcp.sagepub.com/cgi/content/abstract/41/11/1225
according to this, nasal admin has a high bioavailability- around 77%
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