Thread: Melatonin and Tramadol

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    Melatonin and Tramadol 
    Bluelight Crew WorldWarMe's Avatar
    Join Date
    Jan 2010
    I've been on 5-HTP for a while, and the doctor prescribed me Tramadol. I realized that taking these two could be potentially fatal since they both act on serotonin.

    I know that serotonin converts into melatonin, so I have a basic question.

    If I were to take Melatonin, would it be safe to take with Tramadol? I assume that since Melatonin is the final step in the Tryptophan>5-HTP>Serotonin>Melatonin stage, that taking a melatonin pill should have nothing to do with actual serotonin in your brain.

    Would taking Tramadol and Melatonin at night pose a possible risk for Serotonin Syndrome, or are they safe to take together?

    Don't mean to be rude, but I need someone with actual knowlege in this type of field to answer as I need a 100% positive answer.

    Thank you in advance.
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    Bluelighter Mr Blonde's Avatar
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    Oct 2006
    Brisbane, Australia
    There are no interactions that I am aware of and a search on Google didn't turn up anything contraindicating tramadol. There was some information though that melatonin can reduce the effectiveness of anti-depressants, not sure how that works and I might have to look into it. It might interact with serotonin somehow to do this, which could potentially interact with tramadol.

    Are you Rx'd the tramadol for pain?
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