I've been searching the forums for a while now and couldn't find an answer to my question.
As the title says, I'm trying to understand what happens in my brain during MDPV comedown (the biggest problem for me being extreme anxiety).
I think I do understand the comedown and anxiety after a night out on Methylone (bk-MDMA): After ingestion, the drug provokes release of dopamine, serotonine and noradrenaline. After a few hours, most of the serotonine is used up and the synaptical serotonine levels drop to an amount smaller than before ingesting the drug. For whatever reason, dopamine and noradrenaline aren't used up as fast. Therefore, DA and NA levels are still increased. As DA and NA tend to induce anxiety whereas serotonine does the opposite, the increasing ratios of DA to serotonine and NA to serotonine make me feel anxious.
Now I'll try to apply this theory to MDPV: Being an NDRI, MDPV increases the levels of NA and DA without any effect on serotonine. Therefore, I should feel anxious as soon as the drug crosses the BBB. But this is not true in reality. Even though MDPV is supposed to increase DA/5ht and NA/5ht ratios right away, it first gives me a mental high with raised self-confidence and reduced anxiety. Then after a while, these feelings fade away and I'm left with ongoing but "cold" stimulation and skyrocketing levels of anxiety. Redosing can bring back some of the positive feelings and slightly reduce anxiety, but even enormous amounts can't prevent the comedown.
To make a long story short, my theory of high DA/5ht and NA/5ht ratios leading to increased anxiety must be flawed. In fact, the increase of DA and NA levels initially seems to reduce anxiety. Even though, adding MDAI (an SSRA) is said to solve the anxiety problem, a fact that assists my initial theory. So what's the thing I'm missing here?