Like the title says is it safe to take 4 Tylenol 3s if you havenít taken Tylenol in 24 hours? I know you guys are going to say do the cold water tek, but I am not talking about that. I am just wondering if 4 Tylenol 3s is a safe thing. I have taken 3 Tylenol 1s before, and Tylenol 3s have the same amount of acetometaphine as Tylenol 1s. So is it safe to take 4 Tylenol 3s after waiting 24 hours after your last dose of Tylenol 3?