N&PD Moderators: Skorpio | thegreenhand
You're using the wrong terminology. Supplementing L-tyrosine would actually downregulate dopamine receptors via tolerance as it would increase their activation. Overall the net effect would be enhanced dopaminergic activity though of course.
Anyway, there are numerous different kinds of drugs that can increase dopamine levels in the brain. They include dopamine reuptake inhibitors/releasing agents like methylphenidate, cocaine, and amphetamine, dopamine agonists like pramipexole and ropinirole, enzyme inhibitors like MAOIs (phenelzine, tranylcypromine, selegiline, etc) and COMT inhibitors (entacapone, tolcapone), and of course dopamine precursors like L-tyrosine as well as L-phenylalanine and levodopa.
Actually methamphetamine's not a [direct] dopamine agonist or really a reuptake inhibitor (except technically a weak one) -- it's a releasing agent -- but I'll spare you anymore technicalities than that. Okay, one more and that's it -- downregulation and desensitization are synonymous. And yes anything that increases activity at dopamine receptors (including L-tyrosine and methamphetamine) will downregulate/desensitize them to some extent as well.
Anyway, dopamine precursors would work very well for your intention as they'd provide much more dopamine for methamphetamine to release. You'll want to be careful with them though.. a combination of amphetamine and high dose L-phenylalanine sent me into full-blown psychosis once.
L-Tyrosine isn't going to 'sensitize' your dopamine receptors, it's just going to produce even more tolerance in the long run. In any case, if you want stronger effects, I'd suggest either increasing your doses of either L-tyrosine or methamphetamine (or both) or taking a break from them and letting your receptors go back to normal. 1-2 weeks should be plenty of time.
It'll only really 'replenish' your dopamine if you were deficient to begin with. If you take it with excess dopamine activity already going on (as you are with methamphetamine) it'll just result in more tolerance as your body tries even harder to maintain normal levels of dopamine. You'll notice some significantly enhanced dopaminergic effects at first sure but it'll only be a matter of time before tolerance starts to rear its ugly head again and the effects are diminished.
Like I said already I suggest you take a break. Or you could also try augmenting with an anti-tolerance drug like memantine. I've been hearing some really good anecdotes of it blocking stimulant tolerance lately.
As for sources.. this is relatively basic pharmacology knowledge, hence I'm not going to bother.
I guess I am using the wrong terminology, but what I'm asking is, how to have more dopamine for future use. Like lets say i have 10,000 units (Or whatever) How can I get it up to say 30,000? I'm asking cause I take Desoxyn(Methamphetamine) now and it not only works as a DA agonist, it also works like a reuptake-inhibiter, thus resulting in downregulation. Which I think makes you more Desensitized(Right terminology)? I just want to know how to get more dopamine ready for use....
The cream of it all is this: Methamphetamine is a poison with some positive short-term effects. This is not opinion, it is fact. There is simply no sustainable way to keep taking Meth, doctor-prescribed or not, without suffering at the end. .
Since I assume you will ignore what I say above, all I can tell you is make sure you at least take a good vitamin supplement with extra supplementation of Magnesium and Zinc.