Yes, in a small subset of users, Kratom can most certainly cause serious hepatic health complications.
I have been in and out of the hospital for several months now because of it. Decided to try it, liked it, and did it fairly regularly (2-3 x a week) at about 10g a dose. I developed jaundice, extreme liver enzyme levels on several counts (Alkaline Phosphatase 447-570, Aspartate Aminotransferase 375-460, Alanine Aminotransferase 685-834, Urine Bilirubin 6.0, Direct Urine Bilirubin 5.3). Also developed severe RUQ pain approx 6-8hrs post-dose each use.
Needless to say I stopped as soon as I realized the connection between the ingestion of the herb and the symptoms.
If you are taking this medication (it is a medication - whether in herbal form or not), then please do so with the support of a health care provider - or at least pay to get some liver panels done directly after dosing (within 24-48 hrs). If you must lie, tell your doctor you were taking Hydroxycut or another one of those type of dietary supplements which are known to cause liver damage in some people, or tell him you noticed some yellowing of the eyes and skin which spontaneously resolved after the weekend. Whatever it takes to get it done, it's worth it.
If you're killing your liver, it's better to find out about it sooner rather than later. I'm glad I found the link early, or in ignorance I could have caused a much larger problem like chronic liver disease.
Not everyone will have this particular issue, some people may take this plant completely symptom-free, and liver enzymes may remain normal. But is that you? How do you know? And how do you know for sure? Just get a quick blood test at the lab and voila! - instant peace of mind. Too easy.
Good luck to all with this plant. I adore it, but alas, I must admire from afar.