Semorphone is a partial agonist at mu opioid receptors. Its nociceptive value is about 2 times as morphine. I wonder if it would be a good substitute for methadone or buprenorphine specifically. I assume it has poor oral bioavailability just at any N-substituted oxymorphone derivatives so when this would come in powder it would have to be injected or given rectally. If it turned out to be a good substitute in trials, they could make sublingual tablets.
Anyway, so far this drug is not in use but it's known it doesn't produce any toxic effects from available research. I'm looking for some substitute as I'm running out of buprenorphine and I don't want to use any false prescriptions for buprenorphine transdermal patches (their matrix is in foil, there is no liquid inside, so they make perfect for sublingual use).
Does anyone have any further more in-deep information about this drug? I know doses with 100% bioavailability may have to be ~60-80mg for my addiction right now.