beamish - that question is impossible to (safely) answer without more background on your opiate experience/knowledge? How much methadone do you take to get high? How much oxy. For example, if you can handle doing 80mg oxy at once, then these two combined wouldn't be a issue. The same with the reverse - if you can handle 60mg methadone at once, you could handle this. Please give some background on this (your
current tolerance, etc), and every little bit does help. so that we can provide you with the safest and most accurate possible.
[Oh, and don't worry about the methadone blocking the oxy. That is something that happens when you take large doses of methadone daily, essentially oversaturating the receptors so much that its hard to feel the effects of other opiates, but like the guy said, that happens when you have taken something a large dose like like 60-80mg+ a day (and built up a decently sized methadone reservoir as well). You don't have to worry about that, though. there will be no bloackage All should concern yourself with is methadone's long-half life (the ability to feel totally sober while still having opioids in your system), but isn't much of a worry, so long as you sure you take that, and everything, into account when deciding how much oxycodone to take.
Peace! And please, ask any more specific questions in this thread. I will gladly answer them.