^ I don't get what your saying, Opana = Oxymorphone Hcl
No, Opana = mostly cellulose. It's basically a big cellulose pill with a little speck of Oxymorphone in it. I don't know why, but it really bothers me how people on this forum are always posting intranasal BA numbers for crushed pills as though they were pure substances.
are ujoking about the opana/oxymorphone shit ur saying?
if its a joke? goood joke, nice attempt
if not, utFUCKINGse
Not sure what this means. Are you typing while high...?
Well I'll explain. And I'll use hydromorphone as an example, since I don't have any oxymorphone available to weigh. So... a Purdue/Abbott 8mg Dilaudid weighs 150mg. That's a tiny speck of active ingredient and a whopping ~140mg of magnesium stearate.
What does that mean? Well first off, it means that when you crush/snort it, 95% of the matter inside your nose is inert. Only 5% of the active drug is touching your mucus membranes and being absorbed into your nasal capillaries. This is powder we're talking about, not a homogeneous solution that can equalize its concentrations. I would imagine that SOME of the drug is absorbed through osmosis, but most will just sit in your nose, resting on a magnesium stearate barrier. And then your nose will slowly dry out throughout the course of the evening, and the drug will become encapsulated in drying mucus and turn to boogers, which you will later pick and flick. Or perhaps later on you'll simply blow your nose and expel the unabsorbed drug into a tissue.
Simply put, the intranasal BA of ANY crushed pill is nowhere NEAR the BA of the pure substance. And these numbers that are posted everywhere are just blanket statistics. How can it be accurate when it doesn't even take quantity into consideration? Surely, common sense tells you that the less you snort, the more will be absorbed intranasally. I don't know about you, but me personally, my nose can't even hold 100mg of powder. After that, it just goes into my lungs. This is easily verified - just exhale quickly after snorting a line and you'll emit a plume of dusty "smoke." That should be indication enough that the drug is all in your lungs, not your sinuses.
And that doesn't even consider how much slides down from your sinuses into your stomach. Some studies show that 50% of an insufflated drug ends up in your stomach. So now we're essentially talking about oral BA, not intranasal BA.
So yes, these are all the reasons why I know for a fact that the intranasal BA percentages that get plastered all over this forum are useless. How could you blindly believe such a blanket statement? Consider someone snorting 4mg of Dilaudid. That's 75mg. Surely, most, if not all of that would be captured by the sinuses and would be absorbed intranasally. Now consider someone snorting 16mg of Dilaudid. That's 300mg of powder, and I can tell you from experience that huge quantities of it go straight into the lungs, and also down the throat into the stomach. What good are intranasal BA numbers now? It's just a combo of lung and GI absorption.
Please people, use common sense. Maybe the intranasal BA percentages would be accurate if you snorted 20mg, waiting 15mins for full absorption, then irrigated your sinuses, snorted another 20mg, etc. etc. But nobody does that. Who actually irrigates out the inert matter before doing another bump? Like I keep saying, don't believe intranasal BA percentages. Or ANY BA percentage for that matter. Consider rectal BA - how can you be sure that your rectum is fully evacuated? Any fecal matter at all is going to absorb the drug and diminish absorption. And what about oral BA; well certainly that depends on your stomach pH, and the contents of your stomach (e.g. empty stomach? stomach full of fatty foods?), and of course, your specific hepatic function (i.e. CYP450 efficiency, 2Dx/3Ax substrate prolificity).
So no, I don't believe in posting bioavailability figures. I think everyone should try the different ROAs for themselves to determine which works best. Unless you're injecting it, there are quite simply too many variables present which influence absorption, for us to tell you what ROA will work best. After all, the BA statistics that BL'ers so desperately cling to are the same figures that list the oral BA of oxycodone as being higher than the intranasal BA. Yet we all know that snorting OC is more effective than eating it, by a LONG shot. Well, it is for me at least, and that's one of my main points: YMMV.
Sorry for the epic long-winded rant, I'm sorta putting off my work right now %)