Rectal ROA is the only way to go with the 2c-x's I've tried 2c-e, 2c-i, 2c-c, and soon 2c-t-7 and the first 3 have all been better qualitatively along with saving the stash and helping kill any nausea or body load while maintaining the body buzz. Just my 2 pennies but I'll never eat or sniff any 2c-x's ever again, though I may try a small I.M. dose of 2c-e.