What are the suspected neurological interactions between amphetamine and quetiapine (Seroquel)?
I have read that seroquel can actually potentiate amphetamine if, say, taken before sleeping and then taking the amphetamine the next day.
I am guessing this is the result of the quetiapine action as a dopamine antagonist, and in effect it pre-loads the presynaptic vesicles with dopamine by allowing dopamine to accumulate overtime (since no sufficient amount of dopamine is being released due to the DA pathways practically being shutdown by the quetiapine).
However, I have read that for someone who experiences akathisia (which can be caused by amphetamine), quetiapine can greatly exacerbate this.
What would happen if quetiapine was taken while amphetamine was in effect? Would it hault the effects of amphetamine, or would it cause akathisia?