Bluelight

Thread: plugging mscontin (morphine sulfate) what is the bioavailability?

Page 1 of 4 1234 LastLast
Results 1 to 25 of 81
  1. Collapse Details
    plugging mscontin (morphine sulfate) what is the bioavailability? 
    #1
    hello all,
    i read in the bioavailability thread that morphine oral has around a ~30% BA and rectal is around the same. in my experience with liquid morphine i can say that rectally taking liquid morphine is at least twice as strong as oral. i just started getting mscontin pills and plugging them is not as good as plugging liquid morphine for whatever reason but it is still much better than taking them orally. does anyone know the true BA for rectal morphine? i'd have to guess its around 50-60% if not higher. you get a rush and a much stronger high than snorting or taking morphine orally. anyone have similar experiences?

    BA:

    oral ~30%
    rectal ~60%
    insuffilated ~25%
    IV/IM ~100%

    that is the BA chart i'd guess is the most accurate. i dont think plugging is only 5% higher BA than oral.
    Last edited by enoughorangejuice?; 06-07-2009 at 10:59.
    Reply With Quote
     

  2. Collapse Details
     
    #2
    Bluelighter toastedpanda's Avatar
    Join Date
    Jul 2007
    Location
    My Own Headspace, Searching
    Posts
    910
    I don't have actual experience plugging morphine, but I think, in general, that plugging in general has the highest bioavailability next to IV administration.
    Reply With Quote
     

  3. Collapse Details
     
    #3
    yeah i agree i just dont understand why the BA listed on the thread about BA's is only 30-35% when IME it feels more like 50-70%
    Reply With Quote
     

  4. Collapse Details
     
    #4
    Greenlighter
    Join Date
    May 2009
    Location
    Pismo Beach, CA
    Posts
    46
    enema before shafting, and you will be good
    and yeah its much higher than 30%, obviously
    Reply With Quote
     

  5. Collapse Details
     
    #5
    I imagine, and excuse my ignorance, but the BA megathread has reputable quantifiable sources for it's information. I'm pretty sure that was a requirement for said information to be put in the thread.

    I'm not trying to be rude, I hate seeing posts shot down, but if I'm understanding right somebody has already done this in a medical setting, checked blood plasma levels and determined (with repeatability/precision) rectal bioavailability of morphine to be about the same as oral ingestion.

    still, 80% of the ride is subjective, so enjoy.
    Reply With Quote
     

  6. Collapse Details
     
    #6
    Bluelighter TheDankaholic's Avatar
    Join Date
    Apr 2006
    Location
    Boise, Idaho
    Posts
    698
    I know on many occasions I read the BA of Morphine rectally taken is no better then BA of morphine orally taken but i too beg to differ on this. I was prescribed morphine MS Contin for pain relief for awhile when I first started on stronger opiates and plugging MS Contin was atleast 25%-50% stronger feeling to me when taken this way. SO I completely agree with you on this and it's out of months of personal trial and error, not just medical statistics.

    I've been switched over to Hydromorphone instant release now in the form of 6 4mg doses a day. I plug these doses as well now & even though it's a morphine derivative & has the same respective BA issues I feel plugging it "enema" style with a little bit of water and a needless syringe is by the far the most effective ROA to take it.

    So I feel despite the numbers rectal administration of morphine and morphine derivatives are still higher when taken this route.
    Reply With Quote
     

  7. Collapse Details
     
    #7
    When plugging morphine is there a certain amount of water you should use, or does it matter?
    Reply With Quote
     

  8. Collapse Details
     
    #8
    ^ enough so that it dissolves completely
    Reply With Quote
     

  9. Collapse Details
     
    #9
    Bluelighter
    Join Date
    Nov 2008
    Location
    Canada
    Posts
    1,264
    Im thinking of switching to plugging my Novopharm Extended release morphine since I am being weened down,I need to get off the needle.I think it will be my best bet,because I think I would experience withdrawal if I ate them,as I've been IV'ing them since I was at 600 mg's a day,and Im at half that now(IV the whole time,and yes I use wheel filters)

    And I too prefer Morphine too Oxycodone...Oxycodone/Contin is completely overrated and weak compared to IV morphine.
    But yeah....So from personal experience you guys feel the rectal b/a must be higher then oral because of increased effects?or could this just be from faster onset?Kinda how Oxy has a higher oral b/a then nasal,but snorting comes on much faster so therefore seems stronger.
    Reply With Quote
     

  10. Collapse Details
     
    #10
    Bluelighter phatass's Avatar
    Join Date
    Aug 2007
    Location
    A glass bottle in the ocean between waves and rocks
    Posts
    9,404
    i find plugging morphine is twice as strong as taking it orally and hits faster.. but the highest BA is IV..99%
    Reply With Quote
     

  11. Collapse Details
     
    #11
    Greenlighter
    Join Date
    Nov 2008
    Location
    Va
    Posts
    26
    idk ontario... w/ er tabs you should have longer relief from tha wd's. youll crave tha needle regardless so there isnt any sense in plugging since no matter the means you ingest it just cant compare
    Reply With Quote
     

  12. Collapse Details
     
    #12
    Bluelighter
    Join Date
    Nov 2008
    Location
    Canada
    Posts
    1,264
    Yeah the ones I inject dont seem to get as "Syrupy" as the name brand MS Contin,but they do gel,running it through a wheel filter takes care of it.
    Reply With Quote
     

  13. Collapse Details
     
    #13
    Bluelighter lenses's Avatar
    Join Date
    Sep 2006
    Location
    a lotus in the fire.
    Posts
    741
    I believe the BA is around 90% IR. MScontin was my first true drug love and addiction, I clearly remember the first day dosing 70mg rectally and as soon as I got out of the bathroom I was already nodding QUITE hard.

    I was around 14 when I started, and within a year and a half , had gone up to 1500+mgs a day. Funny thing about IR admin, at least IMO, is that the dose seems to "stick around" longer and gets slowly dissipated over the course of 3 days. I remember being able to dose 1.5g and being VERY high for 3 days, and not experiencing any withdrawal symptoms.

    Worst effect was the destruction of my memory. Morphine is one of the worst drugs for your memory. I was in a state of snapshots it seemed, as I had NO memory for a good few months. Would forget I went to the bathroom , etc.

    For the ethex waxy pills that can't be IV'd, plugging is the BEST way to use them. Just be sure to use hot water to melt down the wax, and use a good amount of water too. More water = more surface area.

    I've graduated to banging those beautiful PF 100 pills. Rush as strong as 2 good packs of heroin , but not as heavy as a high. Fun!

    -lenses
    Reply With Quote
     

  14. Collapse Details
     
    #14
    Bluelighter
    Join Date
    Jul 2009
    Location
    New Jersey
    Posts
    94
    I shoot 1 and a half Roxi 30's up my butt every couple days! Even since I tried it for the first time I can't not take them rectally, oral is just a waste to me.
    Reply With Quote
     

  15. Collapse Details
     
    #15
    Bluelighter
    Join Date
    Nov 2006
    Location
    Texas
    Posts
    259
    am I wrong or is MScontin a time release version of oxycontin and the drug is in a form that you can grind it down and it does not release active component???it just releases slowly in your system.... I would guess ass might be better than throuat... butt....geeze....at the point I consider the option of jamming shit in my arm or ass .....thats they day I would look for help.....man ....no buzz is worth shoving it in your ass...
    Reply With Quote
     

  16. Collapse Details
     
    #16
    Bluelighter
    Join Date
    Nov 2008
    Location
    Canada
    Posts
    1,264
    This isn't a place to judge other people man,and it doesn't matter how a drug gets in your system,you're still ingesting the drug.
    Reply With Quote
     

  17. Collapse Details
     
    #17
    Bluelighter
    Join Date
    Nov 2006
    Location
    Texas
    Posts
    259
    Quote Originally Posted by OntarioGuy View Post
    This isn't a place to judge other people man,and it doesn't matter how a drug gets in your system,you're still ingesting the drug.
    ok... I will not judge ...but I remember that the MSContin first came out people tried to break the active component out of the coating it is in... I took it...never in the ass ..butt ......everything that was posted then was that there is amount of crushing or soaking that will help realease the dope...so shoot it swallow or rectal....its still the coating on the active component of drug that slows the buzz.....sure ass is better than oral... but at what cost ???? thats all I am sayin...MS is great for pain control and not so good for hardcore party ....and needless to say......it was the hardest drug I ever quit...it nearly ripped my ass out when I quit...sorry for the pun... but is was that bad.....cocaine was a cakewalk to quit .....
    Reply With Quote
     

  18. Collapse Details
     
    #18
    Bluelighter
    Join Date
    Nov 2008
    Location
    Canada
    Posts
    1,264
    well,You can beat the time release,but not fully,I usually let mine sit in water with a little pinch of vitamin C powder to help release the morphine,(trying to mimic the stomach),then I draw through a cotton,then push back through with a micron filter.When I shoot 200 mg's prepped this way I get mad pins and needles and my face gets very red.

    Im pretty sure Im beating the time release somewhat....and Im sure the same would go for plugging.And another thing is,people think MS Contin is shitty,so when they properly prep it for injection,they greatly overestimate their dose and OD(I've seen it happen)
    Reply With Quote
     

  19. Collapse Details
     
    #19
    Bluelighter PixieDust's Avatar
    Join Date
    Jan 2010
    Location
    La La Land
    Posts
    81
    Quote Originally Posted by TheDankaholic View Post
    I know on many occasions I read the BA of Morphine rectally taken is no better then BA of morphine orally taken but i too beg to differ on this. I was prescribed morphine MS Contin for pain relief for awhile when I first started on stronger opiates and plugging MS Contin was atleast 25%-50% stronger feeling to me when taken this way. SO I completely agree with you on this and it's out of months of personal trial and error, not just medical statistics.

    I've been switched over to Hydromorphone instant release now in the form of 6 4mg doses a day. I plug these doses as well now & even though it's a morphine derivative & has the same respective BA issues I feel plugging it "enema" style with a little bit of water and a needless syringe is by the far the most effective ROA to take it.

    So I feel despite the numbers rectal administration of morphine and morphine derivatives are still higher when taken this route.

    What is wrong with you medically that you have to take dilaudid?
    Reply With Quote
     

  20. Collapse Details
    ms-contin 200mg and dilauted 4mg 
    #20
    I had back surgery in feb 2010 and was doin fine til 6 months later my fusion became inflamed I am now on ms-contin 200mg twice daily and also dilauted 4mg once every 4-6 hours I usually chew the morphine and plug the hydromorphone as the ms contin does not disolve very well do to the wax I'm glad to have the dr. That I have!! I also take mg of xanax per day 30 mg of valume and 30mg of temazepam the nurse at the hosp. Said I shouldn't be alive/breathing ...lol
    Reply With Quote
     

  21. Collapse Details
     
    #21
    do you mean dilaudid?....or did you actually mean dilautid?...if so ive never heard of it.

    also...was "valume" meant to be "valium"?...im just trying to get the right picture here of what medications your taking.

    But if your taking as much medication as I think you are, its no wonder your having trouble typing...haha. Lucky man.
    Reply With Quote
     

  22. Collapse Details
     
    #22
    Bluelighter BIGsherm7272's Avatar
    Join Date
    Dec 2009
    Location
    Tampa, FL
    Posts
    1,598
    Quote Originally Posted by loudaudio View Post
    am I wrong or is MScontin a time release version of oxycontin and the drug is in a form that you can grind it down and it does not release active component???it just releases slowly in your system.... I would guess ass might be better than throuat... butt....geeze....at the point I consider the option of jamming shit in my arm or ass .....thats they day I would look for help.....man ....no buzz is worth shoving it in your ass...
    1. No. MSContin is a time release version of morphine sulfate.
    2. Oxycontin IS the time release version of oxycodone.
    3. There is nothing wrong with plugging. You get more out of your drug.
    Reply With Quote
     

  23. Collapse Details
    wrong spelling 
    #23
    Sorry I'm used to spelling the generics...hydromorphone,diazapam...ect. and ya I'm glad I have a doctor who cares and isn't a pill natzi like my surgeon was,she was gonna put me on the 100mcg fentynal patch but I don't have insurance any more and it was like 500$ per month but I'm happy with my meds I get. 64 hydromorphones every 13 days,unlike most people I wish I didn't have to take pain meds,fuckin 3 spinal sugerys at the age of 26 and it sounds like I will have to be on meds for the rest of my life,by the way is that patch any good?and thanks for pointing out my spelling errors,tommy
    Reply With Quote
     

  24. Collapse Details
    wrong spelling 
    #24
    Sorry I'm used to spelling the generics,hydromorphone,diazapam ect. But ya I'm glad I have a good doctor, I get 64 hydromorphones every 13 days. But unlike most people I wish I didn't have to take pain meds 26 years old and already 3 spinal sugerys,looks like ill be on pain meds for the rest of my life,does anyhone know if thatg fentynel patch is good 100mcgs 72hr time release? And thax for the spell check bud,my spelling does suck
    Reply With Quote
     

  25. Collapse Details
     
    #25
    Greenlighter
    Join Date
    Jul 2010
    Location
    East Coast USA
    Posts
    15
    hope this is not considered off topic but HOW what is the exact method for successfully plugging Ms Contin? Can some one pls refer me or post it pls as i'm new here


    what is the best plugging method for mscontin 100mgs or more
    Reply With Quote
     

Page 1 of 4 1234 LastLast

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •