mitragyna
Bluelighter
- Joined
- Dec 7, 2006
- Messages
- 242
Recently I was switched over to Parnate (Tranylcypromine) from Marplan, hoping that the Parnate would be better for my extremely low motivation. I'm currently in the two-week waiting period, clearing the Marplan from my system.
I was just doing some personal research on Parnate, just to learn more about it's "stimulatory" effects. I came across a link titled "The Clinical State, Sleep and Amine Metabolism of a Tranylcypromine (`Parnate') Addict ". Apparently this dude was taking up to 700 mg a day! I had absolutely no idea that an MAOI could have such abuse potential. I could only imagine someone eating a huge chunk of Cheddar Cheese on 700 mg...probably be suicide! Here's the abstract for anyone curious:
Thanks!
EDIT: I've just found about five more articles on Parnate-addicted patients.
I was just doing some personal research on Parnate, just to learn more about it's "stimulatory" effects. I came across a link titled "The Clinical State, Sleep and Amine Metabolism of a Tranylcypromine (`Parnate') Addict ". Apparently this dude was taking up to 700 mg a day! I had absolutely no idea that an MAOI could have such abuse potential. I could only imagine someone eating a huge chunk of Cheddar Cheese on 700 mg...probably be suicide! Here's the abstract for anyone curious:
Could anyone with experience with Parnate comment on it's stimulant effects? I think this drug is looking promising...hopefully it will work better for my depression/anxiety than Nardil, Marplan, and Deprenyl. They were just OK.The Clinical State, Sleep and Amine Metabolism of a Tranylcypromine (`Parnate') Addict
A twenty-four-year-old male addicted to tranylcypromine is described. He consumed up to 700 mg. daily. While taking the drug he was restless, cheerful and confident. Without it he was apprehensive and housebound.
Large tranylcypromine intake was associated with high muscle tension during sleep and sometimes abolition of the paradoxical or "rapid eye movement" phase of sleep. Drug withdrawal was associated with complaints of dreaming by day, and, by night, an immediate onset and unprecedented duration of "paradoxical" sleep, with nightmares.
The biochemical effects of tranylcypromine at the high dose levels differed significantly from those associated with therapeutic doses. Tryptamine excretion was much increased but 5-HT excretion was not. Blood levels of 5-HT showed a progressive fall, and it is suggested that this may be a result of interference by tranylcy-promine at high concentrations with uptake of 5-HT by platelets.
Thanks!
EDIT: I've just found about five more articles on Parnate-addicted patients.
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