So shouldn't MDAI be an MAO substrate of some kind? Would B or A be preferential?
My experience indicates that if either MAO plays a significant role in metabolizing MDAI, it is more likely MAO-A. I could easily be wrong, as I say this based on the result of one experiment--but I certainly know that the potentiation of the combination with Selegiline, if any, is not close to the potency of combining it very small amounts of 2C-X's.
Following this second experience with MDAI, I can definitely say that the 50mg + 150mg dosage range is the high end of the scale. Indications are that MDAI is more potent than MDMA; for example, the Nichols paper on combining MDAI with dopaminergic agents has data that indicates lower levels of 5-HT for MDAI 3hrs after equal doses of each, implying that more serotonin was pumped out and metabolized/more downregulation occured. The difference isn't huge, though.
Regarding the comedown...this experience is tainted by the strong fear that I had induced some sort of bizarre renal toxicity, not because the pain symptoms actually fit that diagnosis, but because it was too hard to believe I actually had kidney stones strike on both sides within 15 minutes of one another. Plus I wasn't expecting the water retention aspect, so I considered that a symptom at the time. That said, based on my mood the next day and even my general physical state after the trip, and attempting to separate out the negativity associated with the feeling that I had fucked up my kidneys...the comedown seemed very mild.
I think there are two good reasons why I found it so tolerable, but it may not be for others so far: 1) 5-HTP supplementation, both to "top off" stores before/during the experience and 100-200mg taken afterwards/next day, and 2) the wonderful antidepressant effects of Selegiline.
In all, MDAI has a very good, trustworthy feeling about it to me, most notably because of this general lack of body load with simple supplementation even at high doses. bk-MDMA is also rather kind, but has a nastier psychological comedown for me--though I'm not sure I've tried 5-HTP for that, believing methylone to be primarily dopaminergic. MDMA, even with very comprehensive pre/postload supplementation (selegiline, piracetam, 5-HTP, tyrosine, antioxidants, etc) definitely has a higher toll. Finally, a properly supplemented MDMA comedown is a walk in the park for me compared to the acute (~24hrs) comedown from AMT or bk-MBDB.