SWIM was prescribed 30 lomotil (2.5mg diphenoxylate/ 0.025mg atropine) for a stomach virus incurable with just normal loperamide. As soon as SWIMS doctor told him that it was like loperamide but stronger SWIM knew there was potential for a good time (knowing that loperamide is a weak opiate). As soon as SWIM got home he jumped on google to do a little research, just to find out that there are very few first hand experiences with a recreational dosage of diphenoxylate.
The biggest problem which everyone seems to be aware of is the atropine; however, it's hardly a problem. According to this study,
http://www.ima.org.il/imaj/ar02jul-15.pdf, a toxic reaction often isn't seen until 75-100mg of atropine is consumed. However, just like every other drug, there HAVE been people die on clinical doses (as low as 0.5mg in a 65 year old man).
So, let's do a little math, shall we?
at 0.025mg per pill; if SWIM were to take 15 pills this would only result in 0.375mg of atropine being ingested.
SWIM decided to take a total of 14 which would total to be 35mg diphenoxylate and 0.35mg of atropine; what a great choice! SWIM did this by taking 6 pills at t=0 and then taking the rest at t=1.5 hrs; this was a strategic move to let atropine be absorbed by the body (atropine has a very very short halflife, wheras diphenoxylate is long acting). At t=2hrs SWIM described the high to be very comparable to 30mg of oxycodone. The warm, tingling feeling but lasting much longer... nearly 6 hours! SWIM thinks Diphenoxylate definitely lives up to its name as an opioid agonist, SWIM even got all itchy when coming down. All of this and not one negative side effect from the atropine; SWIM is finishing the rest of the prescription tomorrow.