After reading so many posts about fentanyl, I decided to dash in my own two cents, since I am a chronic pain sufferer who has been using fent for a looooong time.
1. For all practical purposes, I must say that Mylan's Matrix patches are absolute garbage. If you are seeking a "rush" from these don't waste your time. You can search the net high and low for a way to "abuse" the Matrix, but unless you are skilled in chemistry, it isn't worth the effort and you'll probably end up destroying the drug. The best way to get the most from the plastic Matrix is to wear on the skin as prescribed, except there are a few things you can do to increase the potency: Scratch and abrade your skin before applying the patch. This removes a layer of dead or semi-dead skin and thus, less skin for the fent to penetrate before it reaches your bloodstream. Apply heat, as hot as you can tolerate. Matrix patches may be abuse-resistant, but the fentanyl still rapidly releases when you apply intense heat such as by a)sitting in a hot tub, b)applying a heating pad, c) blowing a hair dryer directly on the patch or c) get creative! Just don't burn yourself. I personally like to put the kettle on the stove, heat the water to near boiling, and fill my rubber hot water bottle.
Rule of thumb: you can only get so high on Mylan's fent patch. But if you follow the above instructions, you should enjoy a nice three-day buzz, varying in strength depending on dose and tolerance.
ATTEMPTING TO EXTRACT THE FENTANYL FROM THE MATRIX USING FLAMMABLE SOLVENTS OR VOLATILE CHEMICALS IS STUPID AND DANGEROUS. DON'T DO IT!!
2). Real Duragesic patches with the gel reservoirs are obviously the most sought after (or their generic equivalent). There are so many ways to abuse the gel it's almost funny. The nasal spray works (mentioned in a few posts), smoking the gel works quite well, and you can even rub the gel in your eyes for a kick-ass buzz. Orally, use a Q-tip to swab it on your gums or suck on a piece of gauze saturated with gel. Do not swallow or most of it will go to waste.
My personal favorite method is smoking on foil the way one would smoke meth or heroin. The only problem is the extremely short duration which can make for some quickly disappearing patches if you know what I mean.
INJECTING THE GEL, NO MATTER HOW MUCH YOU DILUTE IT, IS INCREDIBLY DANGEROUS. DON'T DO IT. Only inject fent if you have somehow miraculously acquired some ampoules of liquid fentanyl citrate.
Using fentanyl in any way other than wearing the patch will always provide a very short lived high due to the extremely short duration of the drug. This can leave you jonesin' like you've never jones'd before.
Know your tolerance before experimenting with fent. The rest is up to you. If anybody has any questions feel free to ask...I can probably help you as I am not only a long time user but educated in pharmacology. Be safe!