LawnChairSkank
Bluelighter
- Joined
- Jan 19, 2009
- Messages
- 264
Are there any out there? All I can seem to find are the standard phenethylamines and tryptamines.
Only legal fentanyl analogue I've had was 3-Allylfentanyl good luck finding it. I only got it by a very slim chance.
If people are gonna synth an addictive drug , they're gonna synth something well known, not something EXTREMELY obscure, and almost unknown as how to use it, as well as dosages being so small you can barely see it...
Shame. It seems people who like RC's with a passion tend to shun any addictive drugs IME.
I think lack of demand as Tchort cited is most definitely not a factor, plenty of RC customers would love to get faded for cheap on novel drugs.
Herkinorin is an opioid analgesic that is an analogue of the natural product Salvinorin A. It was discovered in 2005 during structure-activity relationship studies into neoclerodane diterpenes, the family of chemical compounds of which Salvinorin A is a member.[1]
Unlike Salvinorin A which is a selective κ-opioid agonist with no significant μ-opioid receptor affinity, herkinorin is a μ-opioid agonist with more than 100x higher μ-opioid affinity and 50x lower κ-opioid affinity compared to Salvinorin A.[2][3] Herkinorin is a semi-synthetic compound, made from Salvinorin B, which is most conveniently made from Salvinorin A by deacetylation, as while both Salvinorin A and Salvinorin B are found in the plant Salvia divinorum, Salvinorin A is present in larger quantities.[4]
Since it is highly selective for the mu opioid receptor, it is likely that herkinorin will be found to produce similar effects to other μ-opioid selective agonists in vivo, such as analgesia and sedation, along with side effects such as nausea, itching, vomiting and respiratory depression which may be harmful or fatal. However unlike most μ-opioid agonists, herkinorin does not promote the recruitment of β-arrestin-2 to the intracellular domain of the μ-opioid receptor, or induce receptor internalisation.[5] This means that herkinorin may not produce tolerance and dependence in the same way as other opioids, although some development of tolerance through other mechanisms has been observed.[6]
Are there any out there? All I can seem to find are the standard phenethylamines and tryptamines.