09-01-2009 13:33
Me and the missus have 10 tablets of Methysergide, each at 1mg. Unortunately I dont beleive this is a suitable amount for tripping, which would start at about 16 mg per person?
So we're probs just gonna use them with MDxx (Preferablyxx=MA, but eh) of some sorts.
Will report on how it goes.
Just wondering, would methysergide be pluggable? Cause then, we might be coming close to LSD trip standard levels...
Ta.
Last edited by *Love*Lite*; 19-02-2009 at 21:07. Reason: title needed to reflect the danger of using the substance
lucky. 4mg=25ug of LSD. So 5mg/person should be enough for threshold effects.
Not a good idea--the interaction effects of methysergide and MDMA are in no way known and might be unpleasant. Methysergide does have affinity for the 5-HT2A receptor, but it has such a low efficacy as an agonist (less than 10% of the effect of 5-HT) that it is unlikely to elicit the same type of effects as LSD or other more active ergoloids. Some people might get effects, other people definitely won't. The fact that methysergide has affinity for all sorts of other receptors might cause a lot of side effects.So we're probs just gonna use them with MDxx.
What on earth is Methysergide? I've never heard of it and it's not on erowid....
Is there any actual report on methysergide on the internet? Or has anyone heard or read a report somewhere and could share it?
If 4mg is equipotent to 25mcg of LSD I wonder why it doesn't seem to be popular anywhere. It wouldn't be very hard for me to buy some here, it's not a heavily controlled substance.
To the original poster I would rather suggest mixing it with weed, as it certainly potentiates low doses of LSD a lot.. MDMA will probably be overpowering, if not dangerous as already mentioned.
Last edited by Blador; 21-01-2009 at 06:27.
well, lets change that. please post a report if you have access and give us an idea of how "LSD like" it is.
I wouldn't mess with this stuff. Especially after taking 3mg sublingual Hydergine today and nearly passing out, sweating bullets, vision whiting out, and then just chilling with a heart rate of around 50bpm all day. I know its not the same thing but sounds close enough to me.
^^ Really? I've never had any particularly troubling side effects with hydergine, even at doses of up to 22.5 mg in a day. Individual sensitivity in response is an amazing phenomenon.
How strange that this makes you trip and people don't really do it. Must have some bad effects...
Then again people still do Dramamine. lol
Okay, sorry bout the late reply!
I am I(medium tolerance to most things), the missus is k (extreme lightweight)
t+0.00-.30 : I: half a bottle of baileys/ half a botle of schnapps over 30
k: 2 cruisers (that gets her pretty tipsy)
t+ 2..00-2.30: Few cocktails, 2 each.
t+3.30-4.00: me,k and a friend buy a 700ml bottle of baileys. i'd say I had half, k had a quarter and the other quarter went to the friend(only drinking)
* WARNING: QUITE POSSIBLY THE WORST COMBINATION EVER, DO NOT TRY*
t+5.30: KFC. disgusting. SO bad. fatty,greasy chicken,popcorn chicken, and chips and BLEUGHRRHRHGUHOQKLNFA Disgusting.
t+6.15: I, and k both had 5- 1mg tablets of methysergide ( also very stupid of us. prescription + alcohol. Stupid. But then again, is that bad considering LSD was used to help treat alcoholics?(or something like that))
then proceed on a train trip homewards, where k throws up about4-5 times, and I'm alright as long as I dont look at her. K reports she did she a few little chiunk s of what looked like tablets.
t+8.30: after a train and car ride home( we werent driving) we get home and go to bed. We were extremely sleepy, K fell asleep in the car, or napped./ wasnt deep just like.. you know what I mean. Very Light sleep.
We lie in bed for ages, contemplating sex, but decide it would end up rolling around in spew.
t+9.30we lie there for about an hour. Awake as anything. Mind is working so fast it wqould be impossible to sleep. BUt there is a little body load.
t.+10.00another half hour passes, and things slowly start moving. just the usual. it looks like the rooms moving(breathing) a bit. some patterns moving in the carpet, not a whole lot. STill wide awake. No crazy thought processes yet.t+13.00. I start trying to trip k out. That is how I normally spend most of my trip, trying to trip people out but in the process making me belive myself aswell. The next 4 hours is spent ccontemplating, feeling things (i.e: each other:P) and me making weird conversation about crazy theories.(as per usual, its just more beleiveable to others now)
t.17.00. starting to really feel more like acid now. where you close your eyes, then open then and you womnder where the fuck you are. I really start rambling crazy now.
t+18.30: we each take a 5mg valium tablet and pass ut for about 6 hours in the most blissful sleep ever with some odd dreams. Couldnt remember a thing about them ceopt they was weird.
In conclusion. Having only 5 tablets each, or 25 ug of LSd, it does resemble acid, and with a higher quantity, it would rather much be like acid, except that it takes alot longer to kick in, but It still does drag on.
I think if taken earlier in the day, without kfc and alcohol it would be rather enjoyable, as It keeps you ALOT more mentally alert and I think it would be less bodyload than normal acid
As for why people dont use it as much. normal acid is probably easier to get than this. this is a prescription for igraines caused form mesntrual pains. SO, only women can get it, and its prescription only. Go figure.
Done.
Is this substance used to treat cluster headache anywhere?
LOL... wish you didn't get drunk before you took it. Kind of skews the report. But thanks!
Sansert is not just prescribed for headaches associated with menstrual pain. BS.
I believe that any psychedelic activity this compound might possess would have to be due to the metabolite methylergometrine (N-[(hydroxymethyl)-propyl]-lysergamide), as the parent compound methysergide is a 1-methyl-ergoloid and those are usually such low-efficacy 5-HT2A partial agonists that they can be considered to be antagonists for all practical purposes.
Methylergometrine, on the other hand, has to be similar to ergometrine in action and ergometrine is a full-blooded active psychedelic ergoloid (and quite an enjoyable one, I might add...although it still doesn't match LSD's almost complete lack of peripheral side effects).
Originally Posted by morninggloryseed
Sansert? Who said this was sansert. I cant remember what it was, but its not sansert, otherwise I would have recognised the name straight away.
Do we have sansert in australia?
Sansert is Sandoz's old name for this medicine.
agreed.
Methylergometrine is more commonly known by the name "methylergonovine"
TiHKAL has some light to shed on this molecule;
WARNING - Methylsergide is known to be a cause of cardiac fribrosis due to it's affinity for the 5HT2b receptor and as such is only licenced for hospital inpatient treatment in the UK.
In other words: Don't, find something else safer to trip with and leave methylsergide for treating what it's prescribed for
This only happens with long term usage.... it does not happen even using it twice a month. Same thing with fenfluramine or any 5ht2b receptor agonist
^ Taking fuck off doses is not going to do you any good & from what I've read, the dose of methylsergide required for psychedelic effects is well beyond the clinical dosage (although yes to get rally worrysome effects generally requires multiple administrations); besides which, taking excessive doses of vasoconstrictors isn't what I'd consider a fun thing to do)
Then you obviously haven't tried it. (Hint, I have). It's not just multiple administrations, its constant administration for around 6 months that causes the fibrosis. In fact, some people on fenfluramine didn't even get the fibrosis after long term treatment. MDMA itself is a potent 5ht2b agonist. So you're suggesting that no one ever does MDMA. Hmm
"we have discovered that the amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its N-demethylated metabolite 3,4-methylenedioxyamphetamine (MDA) each preferentially bind to and activate human recombinant 5-HT2B receptors."
http://www.mdma.net/toxicity/xfenheart.html
^ No it's on my list of 'not worth the potential risk'. The vasoconstricor activity is something that concerns me (as does any possible cumulative effects re: cardiac fibrosis) and yes, I don't take MDMA any more because the side/after effects are just too horrible in my case. I know not everybody taking fenfluramine goes on to develop cardiac fibrosis, but because of the nature of what it is I don't want to take the risk of something like that (others in that category are AET - only tried that once, not to be repeated because of potentially fatal side effects (agranulocytosis), fenfluramine - see aboveas well as a few others)
I'm not suggesting that no-one ever does MDMA (I think you're taking what I'm saying to make over the top statements), nor have I in the past, but I think that people should be informed of any potential risks from the drug they chose to take - after all, methylsergide is only available from hospitals in the UK & they don't implement such measures if there's no dangers associated with the drug
From the BNF
Methylsergide, a semi synthetic ergot alkaloid, has dangerous side effects (retroperitoneal fibrosis and fibrosis of the heart valves and pleura); important: it should only be administered under hospital supervision
also, from side effects under entry for methylsergide
... arterial spasm (including coronary artery spasm with angina and possible myocardial infarction).... Side effects are listed in order of how common they are and the above is found in the first half, so they are not uncommon
And those are for clinical doses, not fucking huge doses well in excess of that used clinically
Are you telling me that the BNF is just being a scaremonger? The warnings concerning methylsergide are much greater than for just about any other psychoactive drug I can find entries for (and it doesn't matter whether or not I've taken it - I wouldn't as I've stated - the BNF is the first ref source for doctors in the UK and the side effects are listed from clinical observations, not theorising what might happen. As such, I'd say that people would be well advised not to consider this a drug suitable for use as a psychedelic, because of all the potential cardiovascular problems)
Last edited by fastandbulbous; 20-02-2009 at 02:11.
does not sound worth it when there's good ole lucy to be had
01-03-2009 05:17
A very well thought out and quantified scientific post. The only other risk is the possible side effect of excess vasoconstriction, and no one can really say much about that because no scientific studies have been done measuring the effects of taking a large dose. However, it is evident in TiHKAL that it has been tested on several subjects at high doses without detrimental effects.I agree, but when there's none to be had it makes for a cheap, easily accessible alternative.
With regards to the primary risk, cardiac fibrosis, it's important to compare the dosing. Sure, it's a risk for chronic usage of 3mg per day for more than a few months (from the Australian Medicines Handbook: "Do not use for >4-6 months without a break of 1-2 months because of the risk of fibrosis"). The risk is not directly related to the total amount you've consumed, it is due to the duration of time which your body has been consistently exposed to the drug (ie taking 3mg/day for 3 weeks =/= taking 63mg at once). Fibrosis is a chronic process, and as such taking a large dose at once will not result in pathological fibrosis.
I'm not saying there are no risks associated with taking more than prescribed, just not fibrosis. Taking 63mg would potentially have some nasty side-effects.
Wtf is that supposed to mean? You think a psychedelic trip is worthless? Good for you - I happen to quite enjoy it. Either that or you meant it literally, in which case I would like to know which drugs you take recreationally that are actually good for you.
I have tried methysergide (19mg) and it was very enjoyable. I found the psychedelic effects were indistinguishable from LSD.
Bluelight
