I've searched and searched every website on the web looking for anything negative as far as long term side effects or side effects goes. I've found nothing that says that oxycodone can damage you in the long term. Is it good for you then? Cause i havn't read anywhere that its bad for you. I havn't even read possible liver damage or anything, its acetaminophen is bad for you so what is oxycodone? What about hydrocodone also? Are opioids a miracle drug? I just can't find anything negative about it other than resperitory depression or addiction.