• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Bupe Tramadol and Suboxone

When I came off OC using suboxone, I also took tramadol before the subs, after the subs, it doesnt matter, there is no precipitated w/d. Suboxone didnt act as a pain releiver at all, and Tramadol was prescribed by my Sub DR. for pain. Good luck. Remember to slowly taper your last couple weeks off Sub or you will still w/d.
 
Jond2005 , I got your message , the problem is : "Sorry, but you may only send Private Messages to members of staff until you reach Bluelighter status." ... so , given such inconvenience it would be best for you to submit your E-mail in here or simply send it to me in a PM so that we can talk on Msn or Skype for instance ...
 
Tramadol is a very unique opioid in that in addition to its traditional u-opioid agonism (where it is a very weak agonist), it is an SNRI. Its pharmacological significance is manifested by its main metabolite, which is the CYP2D6 O-demethylated product called M1. M1 has about 200 times the u-opioid agonism of tramadol and so is still a rather weak opioid, with u-agonism of about 1/30 of morphine. Tramadol's analgesic (or more correctly, pain-killing) ability reside in a synergism between weak opioid receptor agonism, and weak serotonin and norepinephrine reuptake inhibition. Norepinephrine signalling has been implicated in relieving neuropathic pain and severe pain that is often unaffected by traditional u-opioid agonists. Tramadol's recreational use resides also in a synergism between these three systems. The SNRI activity of tramadol takes place very rapidly and can produce a mild euphoria, though more commonly a pleasantness or mildness of manner, a mood-brightening effect.
The reason that tramadol can be used concommittantly with buprenorphine is that buprenorphine WILL antagonize tramadol's opioid activity, but will have no effect on its SNRI activity, except possibly to slow the degradation of M1 via enzymatic inhibition. Since little or at least only some of tramadol's pharmacological activity is in its opioid agonism, buprenorphine will only antagonize some or little of its effects and will unlikely cause precipitated withdrawal, especially because buprenorphine itself has far stronger u-agonism than tramadol or M1.
 
ultram doesn't get me high. All it does is make me vomit. No other "opiate" does that. I can't stand those things. And to think they gave it to me because it was "gentler on the stomach". LOL. Yuck.
 
I don't understand the great hype over tramadol, it's just like a weak body high for me... but yeah I've taken both several times before/afterwards/simultaneously and it's fine.

ultram doesn't get me high. All it does is make me vomit. No other "opiate" does that. I can't stand those things. And to think they gave it to me because it was "gentler on the stomach". LOL. Yuck.

There is some truth in what you two write, and some things that are just plain incorrect.

Tramadol is not a high like oxycodone, or even hydrocodone, or any opiates above the stength of the two mentioned. However, It is unschedualed, this means that it is more liberally prescribed, benefit #1.

Benefit #2 it is an effective pain reliever, it doesnt have nasty apap (most of them, I know ultracet has 37.5mg of tramadol hcl, and ?00mg of apap). Most tramadol scrips do not have apap.

Benefit #3 It has anti-depressant properties. It is not "euphoric" except to an opiate niaive person, or someone who hasnt ever tried it, for the first couple times. However, as the months go on, it still has its mood elevating properties, and its pain relieving qualities. Takes away all my knee pain and I can walk around, work out, and do whatever. Without it, knee makes a clicking sound when i extend it, and it hurts. Alieve, tylenol, or aspirin only take away some of the pain.


So basically. Yes, there is no "hype" as you say. Its not oxymorphone, its not fentanyl, its tramadol. And for what it is, which is not a true opiate, its effective. Granted over time it loses its punch, but dont all meds? Overall its a nice mood lift, and some pain relief. A tough guy like you who doesnt feel tramadol should graduate to bigger a better drugs 8o
Tramadol is no Oxycodone, but its meant for a different level of pain. If you are in a car crash, and you break an arm, or leg, you will be given some strong narcotics, ya know, the kind famous people get addicted to afterwards. Meanwhile, a more chronic, nagging pain, mild, would be better treated with a med like prescription strength ibuprofen, tramadol, and similar pharms, I.E.
**Darvocet, which is an opiate, although, a truely crappy one, where the negatives IMO outweight the benefits((hence why the U.S. gov't considered taking it off the market, due to its high APAP amount, and like I said, lack of benfits for potenetial problems**
*****And to just clear things, Tramadol is an OPIOID- it does not come from the poppy (papaver somniferum) plant, and is a "Quasi narcotic". IT acts similarly to opiates in pain relief, regarding its effect on certain opioid receptors, which changes how pain is felt from the brain - to the body.
Opiates = Drugs that derive from the poppy plant. Everything from Codeine to heroin. Not tramadol.
 
Last edited:
Damn Colmes. You're freaking ridiculous. What are you going off on a rant for? I just said tramadol doesn't do much for me and I don't see why my opinion towards the stuff can be declared "incorrect". You don't need to go all tramadol 101. I know what the stuff is and I don't need definitions of what an opioid and opiate is. Seems like you've been taking too much of the stuff.
 
so I've been on this combo , namely 4mg Subutex & 200mg Tramal slow release pills, for 3 months now...surprisingly enough I just found out that somehow this is what it takes for me to stay away from my 1g(roughly)/daily H habit, yet I'm pretty positive there will be a price to pay in the future whenever I decide to pack it all up altogether...was just wondering if there are people in here who have had the experience of quitting this combo and possibly share the details with me so that I can know more or less what to expect when time comes for me to quit... thanks in advance<3
 
so I've been on this combo , namely 4mg Subutex & 200mg Tramal slow release pills, for 3 months now...surprisingly enough I just found out that somehow this is what it takes for me to stay away from my 1g(roughly)/daily H habit, yet I'm pretty positive there will be a price to pay in the future whenever I decide to pack it all up altogether...was just wondering if there are people in here who have had the experience of quitting this combo and possibly share the details with me so that I can know more or less what to expect when time comes for me to quit... thanks in advance<3

I don't have a whole lot i can contribute here but i'll try.

First of all i got a bottle of those 200mg XR tramadols once, i would chew them even though they were SUPER hard and tasted like battery acid.

I chewed three of them at 3am in w/d one night and all it did was stop my RLS which was actually helpful.

Anyways, i don't think the tramadol is going to give you a whole lot of trouble. In comparison to buprenorphine its like a marble to a boulder.

I would wean yourself off the trams first and then go for the bupe. Hopefully someone else has something more worthwhile.
 
Dude Tramdol and Suboxone together kick ass! Subs + Trams = very good high..


Iv only mixed them both a few times( very unlike mixing H and bupe, Bad), so I dont have that much expierence with tramadol, a ton with subutex though. The thing that Iv heard and also found to be some what true is that Buprenorphine(in this case subutex) and tramadol and subs have a somewhat synergenic affect to be kinnda true. Due to the fact that they are both atypical opiates....right?
 
but yeah,after having tried to quit H countless times through various differents ways I found out what is it that keeps me "balanced" , and that is exactly it , even though I started on higher doses I've stabilized at 200mg Tramadol/4mg Subutex and the odd 0.25 alprazolam here and there , been on this combo for the last couple of months and I feel no need whatsoever to go back to my 1 gram a day H habit...I hope this is helpful to some of you cause like stated above I tried pretty much everything else before from Methadone to antagonists , pretty much all benzos and anti depressives out there without any6 success , this time around I just got it right thankfully...the synergetic effect of these pharms taken simultaneously works marvels for me and contrary to a lot of horror stories I see in these forums regarding Trams I have had no problems whatsoever in maintaining that 200mg daily dose , some days I even do less and no noticeable discomfort... I might be wrong but nothing and I mean NOTHING will ever get anywhere near to mess you up as much as H does, all other withdrawals are a pic nic in comparison...bring on the bash lol
 
I might be wrong but nothing and I mean NOTHING will ever get anywhere near to mess you up as much as H does, all other withdrawals are a pic nic in comparison...bring on the bash lol

Definitely wrong.

For some, a heroin withdrawal would be a picnic compared to what they've been through. Alcohol WD including delirium tremens is worse than kicking heroin, and so is benzodiazepine WD including seizures.

There's probably other drugs harder to kick than heroin too based upon horrible physical withdrawal, I couldn't name any except for speculating, so I wouldn't want to do that. I'm sure some people could confirm that meth or crack would be a worse WD, however I'm just speculating with those two. Maybe they're not.
 
yet I'm pretty positive there will be a price to pay in the future whenever I decide to pack it all up altogether...was just wondering if there are people in here who have had the experience of quitting this combo and possibly share the details with me so that I can know more or less what to expect when time comes for me to quit.
Anyways, i don't think the tramadol is going to give you a whole lot of trouble. In comparison to buprenorphine its like a marble to a boulder.

I've never been through any opioid withdrawal so I don't have any firsthand experience, but from reading through many hundreds of posts on here and erowid, I can say that it's a big mistake to suggest that tramadol WD won't "give you a whole lot of trouble" and anyone who's kicked a 300-400mg habit will attest to that. I think most would say that the tram WD is far worse than a bupe WD in terms in intensity but not quite in terms of longevity, where bupe is supposed to a king, taking much longer than most other opioids, even though tram WD is also longer than most. The tram WDs are so bad because it's an opioid AND an SNRI, so WD is an opioid WD and SSRI discontinuation syndrome at the same time, not to mention that seizures are pretty common during tram WD (as they are during tram binging).
Being that you're taking tram with bupe, most likely the main effects of the tram are the SNRI properties and you are experiencing very little mu-opioid effects from the tram itself due to bupe's ungodly inhibition of mu-opioid receptors, so to my knowledge, the best way to approach quitting both of these would be to first taper off the tram so that you experience mostly only the SSRI discontinuation syndrome, and then slowly tapering off the bupe after being completely clear of any tram WD. If you were to do it the other way, while tapering the bupe off, you'd just feel more and more of the tram mu-opioid effects replacing bupe's and would have moderate opioid WD during that, but then while tapering the tram, you'd have both opioid and SSRI WD, which together are epic and dangerous by any standards.
In any case, small doses of xanax or any other benzos can greatly help during WD of both drugs, especially due to its opioid-sparing effect wherein it increases an opioid's effect at any given dosage, not to mention that it reduces the seizure threshold which will be highly recommended during tram WD.
Anyways, good luck with all of that and congrats for your accomplishment so far in tapering down to your current dose. Most importantly, if possible at all, talk to a doctor and/or an addiction specialist about these things cause they know more than any of us. There is plenty of more information around on the net, especially BL, about quitting this combination and tram and bupe by themselves. I hope this helped some.

To your success,
-Jaguraguguru
 
1st and foremost I'd like to thank you,Jaguraguguru,for your opinion,advice,attention you've shown/voiced regarding my case. In any case,what you just typed makes perfect sense and that is excatly the route I'll be taking in the near future,as in I'll be tapering down the trams first till I reach 0 and then hopefully Subutex(2mg) will be enough to deal with an hypothetic Tramadol WD ,if not I'll increase the dose to 4mg and see how it goes,at a later date I'll simply be tapering the bupre down to 0 as well possibly with the aid of small benzo doses,nothing exceeding 0.50 mg alprazolam cause I know how awful benzo WD can get if used/abused recklessly...another problem is the fact I have easy access to Tramadol as in my GP writes me them 6 months prescriptions which allow me to purchase any quantity of these things...oh well,hopefully I'll be able to deal with temptation in the same way I just dealt with an obsessive H addiction,thanks again for your words on the matter and hopefully who knows?Perhaps this combo will be helping out people with the same H issues I used to have. take care mate.
 
I had a bottle of tramadol once after i started taking suboxone. I'm on 16 mg a day and i took 7 of the 50 mg ultrams and it actually had me feeling pretty damn good. suboxone+tramadol is definitely a good combo, suprisingly.
 
^Couldn't agree more ,it's been 7 months roughly since I started using both Tramadol and Subutex combined in order to quit a H habit and this combo works wonderfully for me , as I think I said above Tramadol on its own does NOTHING whatsoever for me regardless of the quantity yet when I combine it with bupre (even at low doses like 200mg/Trams) it has this great effect as if I was to be on some sort of strange full agonist even=D
 
agreed, great synergy, and a VERY long duration; 150mg tramadol (extended release) with 1mg sublingual buprenorphine will give me a 10+ hour pinpoit-pupil high, followed by a LONG period of slight mood enhancement. when i re-dose with insufflated buprenorphine and/or instant release tramadol, the effects are greatly amplified (even though re-dosing opiates often isn't very effective in my experience). for me, the high is active & stimulating, with little sedation. higher doses kinda feel jittery, but i think they're fantastic when combined with a (long acting) benzo.
 
^If I had made a more detailed description of what the Bupre/Tram combo does for me it would exactly match the one you just did ... that's exactly it , right down to the amplification of effects whenever I'm to redose with either insufflated bupre or more oral Trams some hours later ...very odd how both pharms work so well together (and yes , I also tend to use very small doses of benzos(0.5/1mg Alprazol) whenever its synergy is to make me jittery)
 
hahha , if I was to be a physician I'd definitely recommend this combo for issues like Depression (which I suspect I suffer from, even though never officially diagnosed):\
 
Top