fastandbulbous
Bluelight Crew
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- Jul 29, 2004
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Cimetidine inhibits CYP2D6, so if you're using it in conjunction with a codeine derivative, that's a step backwards
N&PD Moderators: Skorpio | thegreenhand
Advanc3d said:also what will happen to the high of MDMA when taken with CYP3A4 inhibitor?
aj1976 said:MDMA is first metabolized by CYP3A4 (N-demethylation) to MDA.
Both are then metabolized by CYP2D6.
There are other enzymes involved in this, although 2D6 is the primary enzyme for metabolizing MDMA. I suspect taking MDMA with a 3A4 inhibitor may not make that much of a difference.
I don't know if oral contraceptives are metabolized through this pathway but IF SO, then:Advanc3d said:if you take Quercetin (CYP3A4 inhibitor)
would that render contraceptive pill useless? considering the pill requires that enzyme to metabolise?