What you've witness is the power of Madison Avenue marketing. My doctor, who chastized me for smoking marijuana and being an all around druggie, was all like Vyvanse is fucking great, meth/weed is bad. The reason is because Shire has brainwashed everyone into thinking Vyvanse actually represents an advance in ADD treatment. Why take risks and spend billions on new shit that probably won't work when you can tweak(ha!) an already effective drug, the 130 year old amphetamine, then advertise and promote the shit out of it, and make just as much money. The theory in developing lisdexamphetamine was that it would be broken down by trypsin and it could be only taken orally, and even then there'd be a ceiling dose that would overwhelm the trypsin. However if you look at the FDA approved prescribing information(
http://pi.shirecontent.com/PI/PDFs/Vyvanse_USA_ENG.pdf), under clinical pharmacology and drug abuse and dependance, you'll see that lisdexamfetamine is metabolized by the blood cells quite rapidly and primates including humans liked IV lisdexamfetamine, not as much as IV coke or plain dextroamphetamine, but still way more than placebo.
It's not suprising Shire is doing this scam, they did the same thing with adderall. The mixed salts in Adderall were supposed to have a different absorbtion rates. But if you look at the prescribing info for Adderall(
http://www.rxlist.com/adderall-drug.htm) and compare it to plain old dexedrine(
http://www.rxlist.com/dexedrine-drug.htm) you'll see both had similar half-lives and similar peaks in 3 hours. They probably mixed dextroamphetamine with amphetamine to copy the infamous Biphetamine, which was a very popular street drug from the 60's-80's. Hell the levoamphetamine probably only adds side effects, no suprise adderall was once pulled off the market in Canada and other countries.
As to why nobody has shoot it, I'm almost certain someone has, just no ones posted about it on the internet yet. Really the kind of people who would slam it would rather get meth/coke. The average tweaker does more methamphetamine in a day then the maximium medical doses of amphetamine in a month.An ADD script isn't going to replace your dealer. Adderall isn't much of a street drug, it's shit college students take to balance work, party and study and to counteract fatigue from all that and sleep depravation, not so much to get high. Not many people IV adderall/dexedrine either, even though you could. It won't be great like IV dexedrine, probably won't have much of a rush, but it would feel stronger. I'd probably be like IV codeine, stronger but no rush like morphine.
But Vyvanse isn't the only prodrug of amphetamine. There are TONS, all generic so there's no money in studying them for ADD.Clobenzorex, Fenethylline, Amphetaminil, benzphetamine, dimethylamphetamine, fenproporex, mefenorex, phendimetrazine(not an amphetamine but similar), the list goes on. Prodrugs of amphetamine isn't an original idea. Many probably got lower abuse potential than lisdexamphetamine.
