URB-597 Experience
Introduction
As a sufferer of depression and anxiety, and a daily abuser of marijuana, I was very curious when this recently came onto the market. Studies have touted this drug to have success in treating depression, improving memory, aiding in withdrawal from cocaine and nicotine, reducing post traumatic stress, pain relief and more. Unlike THC and most JWH's, URB is a reverse antagonist, so instead of artificially causing the CB1 and CB2 receptors to fire, it induces the body's natural cannabinoid receptor juice. Actually it just reduces the natural breakdown to allow for accumulation. Kadmus pharmaceuticals, based in Irvine, filed for the original patent on the drug. They later sold the rights and all of the research along with it to a company called Organon. Hundreds of studies have already been completed showing powerful anti depressive and analgesic qualities in rats. Human clinical studies are currently being formed. Because it is not a direct antagonist, it diverts all known state and federal bans targeting JWH and similar chemicals commonly found in "Herbal Incense". I must admit, It all sounds very promising. Currently research chemical suppliers have made this substance readily available to the general public.
8-19-11
After researching the various data, URB597 doesn't seem particularly toxic on the molecular level, however a similar reverse antagonist for cb1 and cb2, "rimonabant" resulted in all studies being shut down due to causing anxiety and depression. Due to the fact that several major research chemical distributors are promoting and selling this as a JWH alternative, it's difficult to trust the currently posted user experiences. Tampering with the delicate balance of our endocannabinoid system might possibly adversely affect our brains natural maintenance routines and functions controlling memory and reward systems. However, URB-xxx's might have potential to be an amazing anti-depressant or therapy to aid in marijuana withdrawal. As i continue to research this promising pharmaceutical, I will post my findings to this page.
8-24-11
I have ordered a gram of 99% pure URB-597. In various animal experiments, dosage was administered both orally and intravenously. A few reports claim users have received positive effects from smoking UBR597. Vendors are claiming synergetic effects when blended with other cannabinoids. All things considered, I set out to make a blend using the ratio of 1:50, URB597 and damiana respectively. The typical oral dose is anywhere from 1-7mg. With this blend, each gram should contain .02 g, if each gram was four bowls, each bowl should contain .005 g and contain roughly one dose. What is my reasoning for smoking this substance? One is to analyze if the substance is at all active. Another is that, if it is active, the duration of effects probably won't be a full 24 hours as reported with oral ingestion. Why am I even testing this substance? I want to see if it can provide any benefit to me in reducing cravings for marijuana. I also want to see if has any potential as a recreational drug.
FIRST REPORT
For my experiment, I sustained from marijuana for several hours. By this point I was really craving a bowl. When preparing the URB based herbal blend, curiosity got the best of me. I eyeballed a small amount, probably about .001 g. or less and ate it. Within 10-15 minutes my cravings for a bowl dramatically diminished. My focus seemed to improve. I finished mixing the blend and left the room. I really had the desire to start a project so I searched around the garage for my super8 projector I've been meaning to work on. My focus and concentration was suburb for roughly two hours as I tinkered with the projector. I felt clear headed, no anxiety, and no building of negative thoughts (very untypical for me). It seemed like I was under the influence of a very mild cannabinoid, similar to RCS-4 without but without the "head change." I experienced what I thought was a slight euphoria, and possibly a heightened sense of awareness, but the most profound effect was the lack of desire for marijuana. This however diminished at the end of the two hours, and I started to feel an up-tick in frustration levels. By this time my herbal blend was finished drying, so I decided to give smoking it a shot. I did finish up some weed in my pipe before packing in the URB597 blend. I took one hit, then decided to wait before continuing with. So far I feel what might be a synergistic effect from both substances. It's a very calm stoning sensation, much like a powerful sativa. I feel remarkably clear headed / focused for having just smoked pot. In a way it seems to cancel out some of the typical euphoria caused by THC. Was very difficult to wake up in the morning. Probably one of the most effective and fast acting antidepressants i've tried, and I've tried a lot including effexor, prozac, paxil, zoloft, xanax, ativan, luvox, nortryptelene, welbutrin and more. I've become very in tune to how a chemical makes me feel.
UPDATE
I was taking URB-597 daily for four days orally. The anxiolytic and antidepressant effect was still present, but diminishing each day despite increased dosage, much like a cannabis tolerance. I haven't gone back to the herbal blend since that first try. I was satisfied with the oral dose. Each day I took it, it was difficult to wake up the following morning. Two nights ago was my final dose, in the morning. Later on that day I drank a few beers and got unusually sick. Like most synthetic canabinnoids it seemed to have a negative interaction with alcohol.
CONCLUSIONS
• An effective antidepressant and anxiolytic
• Effects can be achieved orally or by smoking
• Helps satisfy the urge to smoke marijuana
• Makes it more difficult to wake up in the morning / causes sleepiness
• Does not cause munchies, if anything it might suppresses appetite
• Nearly tasteless
• Diminished sexual appetite
• Do not mix with alcohol
• Effects reminiscent of 5HTP but stronger
Introduction
As a sufferer of depression and anxiety, and a daily abuser of marijuana, I was very curious when this recently came onto the market. Studies have touted this drug to have success in treating depression, improving memory, aiding in withdrawal from cocaine and nicotine, reducing post traumatic stress, pain relief and more. Unlike THC and most JWH's, URB is a reverse antagonist, so instead of artificially causing the CB1 and CB2 receptors to fire, it induces the body's natural cannabinoid receptor juice. Actually it just reduces the natural breakdown to allow for accumulation. Kadmus pharmaceuticals, based in Irvine, filed for the original patent on the drug. They later sold the rights and all of the research along with it to a company called Organon. Hundreds of studies have already been completed showing powerful anti depressive and analgesic qualities in rats. Human clinical studies are currently being formed. Because it is not a direct antagonist, it diverts all known state and federal bans targeting JWH and similar chemicals commonly found in "Herbal Incense". I must admit, It all sounds very promising. Currently research chemical suppliers have made this substance readily available to the general public.
8-19-11
After researching the various data, URB597 doesn't seem particularly toxic on the molecular level, however a similar reverse antagonist for cb1 and cb2, "rimonabant" resulted in all studies being shut down due to causing anxiety and depression. Due to the fact that several major research chemical distributors are promoting and selling this as a JWH alternative, it's difficult to trust the currently posted user experiences. Tampering with the delicate balance of our endocannabinoid system might possibly adversely affect our brains natural maintenance routines and functions controlling memory and reward systems. However, URB-xxx's might have potential to be an amazing anti-depressant or therapy to aid in marijuana withdrawal. As i continue to research this promising pharmaceutical, I will post my findings to this page.
8-24-11
I have ordered a gram of 99% pure URB-597. In various animal experiments, dosage was administered both orally and intravenously. A few reports claim users have received positive effects from smoking UBR597. Vendors are claiming synergetic effects when blended with other cannabinoids. All things considered, I set out to make a blend using the ratio of 1:50, URB597 and damiana respectively. The typical oral dose is anywhere from 1-7mg. With this blend, each gram should contain .02 g, if each gram was four bowls, each bowl should contain .005 g and contain roughly one dose. What is my reasoning for smoking this substance? One is to analyze if the substance is at all active. Another is that, if it is active, the duration of effects probably won't be a full 24 hours as reported with oral ingestion. Why am I even testing this substance? I want to see if it can provide any benefit to me in reducing cravings for marijuana. I also want to see if has any potential as a recreational drug.
FIRST REPORT
For my experiment, I sustained from marijuana for several hours. By this point I was really craving a bowl. When preparing the URB based herbal blend, curiosity got the best of me. I eyeballed a small amount, probably about .001 g. or less and ate it. Within 10-15 minutes my cravings for a bowl dramatically diminished. My focus seemed to improve. I finished mixing the blend and left the room. I really had the desire to start a project so I searched around the garage for my super8 projector I've been meaning to work on. My focus and concentration was suburb for roughly two hours as I tinkered with the projector. I felt clear headed, no anxiety, and no building of negative thoughts (very untypical for me). It seemed like I was under the influence of a very mild cannabinoid, similar to RCS-4 without but without the "head change." I experienced what I thought was a slight euphoria, and possibly a heightened sense of awareness, but the most profound effect was the lack of desire for marijuana. This however diminished at the end of the two hours, and I started to feel an up-tick in frustration levels. By this time my herbal blend was finished drying, so I decided to give smoking it a shot. I did finish up some weed in my pipe before packing in the URB597 blend. I took one hit, then decided to wait before continuing with. So far I feel what might be a synergistic effect from both substances. It's a very calm stoning sensation, much like a powerful sativa. I feel remarkably clear headed / focused for having just smoked pot. In a way it seems to cancel out some of the typical euphoria caused by THC. Was very difficult to wake up in the morning. Probably one of the most effective and fast acting antidepressants i've tried, and I've tried a lot including effexor, prozac, paxil, zoloft, xanax, ativan, luvox, nortryptelene, welbutrin and more. I've become very in tune to how a chemical makes me feel.
UPDATE
I was taking URB-597 daily for four days orally. The anxiolytic and antidepressant effect was still present, but diminishing each day despite increased dosage, much like a cannabis tolerance. I haven't gone back to the herbal blend since that first try. I was satisfied with the oral dose. Each day I took it, it was difficult to wake up the following morning. Two nights ago was my final dose, in the morning. Later on that day I drank a few beers and got unusually sick. Like most synthetic canabinnoids it seemed to have a negative interaction with alcohol.
CONCLUSIONS
• An effective antidepressant and anxiolytic
• Effects can be achieved orally or by smoking
• Helps satisfy the urge to smoke marijuana
• Makes it more difficult to wake up in the morning / causes sleepiness
• Does not cause munchies, if anything it might suppresses appetite
• Nearly tasteless
• Diminished sexual appetite
• Do not mix with alcohol
• Effects reminiscent of 5HTP but stronger
