MattPsy
Bluelighter
- Joined
- Jan 15, 2006
- Messages
- 1,616
Acyl: That method sucks.
Oxidative decarboxylation of tryptophan to yield the nitrile with TCCA. Easy hydrogenation to the amine. Then reductive amination with formic acid & formaldehyde to yield DMT (in-situ formation of imine and reduction to alkylated amine from formic acid as hydride source).
Oxidative decarboxylation of tryptophan to yield the nitrile with TCCA. Easy hydrogenation to the amine. Then reductive amination with formic acid & formaldehyde to yield DMT (in-situ formation of imine and reduction to alkylated amine from formic acid as hydride source).