Is there any interaction? I've heard that some ssri's inhibit the effects of Morphine and Codeine. Ever since I started Prozac treatment opiates haven't been enjoyable. Anyone have any expierence or knowledge on the subject? I've searched around and haven't found much.
EDIT: found this on erowid.
"Some drugs also interfere with cyp2d6. Prime among these are the SSRIs, with the exception of Zoloft (if I remember correctly). The most potent inhibitor is paroxetine (paxil), followed by fluoxetine (prozac). If you are taking an SSRI, you will probably experience a markedly decreased euphoria when using codeine. (Paxil has a half life of only 24hrs, so not taking it for a few days will do miracles; the half life of prozac is 7 days"
Does anyone know how long after taking Fluoxetine (PROZAC) that your inhibitory effects of CYP2D6 Return to normal after long term use?
Also, can anyone tell me if escitalopram (LEXAPRO) inhibits CYP2D6?
Or just any information in general about the interaction of the CYP2d6 enzyme and antidepressants. Or the interaction between Prozac and Oxycodone.
I feel much less Euphoria when taking Oxycontin with Prozac. I'm trying to calculate how long I need wait until I can feel the desired effects.
Also I suffer chronic depression and anxiety and I'm trying to figure out an SSRI that mixes well with opiates.
Any help is greatly appreciated.