I have acquired a decent supply of Ritalin and Adderall and find them both to be individually effective recreationally and as "study aids." Anyways, I am interested in what the effect would be in combining the two, as I am aware that they activate different mechanisms in the brain in order to primarily effect dopamine.
As I understand it, amphetamines such as Adderall basically work by releasing more dopamine into the synapse so more dopamine receptor cells can be activated for a longer period of time. Now, Ritalin (Methylphenidate) works as a dopamine reuptake inhibitor, meaning that it partially blocks dopamine transporters that remove "used" dopamine from the synapse. By inhibiting its reuptake, more dopamine collects in the synapse than normal and thus the dopamine receptor cells become overstimulated.
Anyone who knows the neuropharmacology of amphetemine or methlphenidate better than what I just explained please correct me and fill in the details. My question, though, is this: would Adderall and Ritalin somewhat "cancel each other out" if taken together or would they in fact act in synergy, each one potentiating the effects of the other? From my simple explanation above, I am somewhat inclined to believe that they would work in synergy with Ritalin functioning as a reuptake inhibitor and thus allowing the excess dopamine released into the synapse by Adderall to stay active longer. However, I have heard people claim otherwise and was wondering if anyone could provide a chemical explanation of exactly how they interact with each other and whether it is a worthwhile combination.