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    Reducing or preventing tolerance to psychedelics (Please move this to ADD) 
    #1
    Bluelighter almost-'s Avatar
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    I've now recently started tripping 4-6 times a week. I think I have some tolerance issues.

    I also use ketamine all the time with psychedelics and very often GHB also.

    Read more about psychedelic-addiction:
    http://trippi.info/psyvault/viewtopic.php?t=631

    Today I have taken 3,5mg of DOC IM and 2mg p.o. Maybe 1g of Ketamine IM (usually 60-120mg at once). 40-60mg of 2C-E. Some Methylone. Some Meth. Some Cocaine. Some GHB.

    It's quite expensive to use that much drugs everyday, but I think that especially psychedelics and ketamine have changed my personality in a very wonderful way. I used to be very depressed, but now life seems like a wonder ride.

    I'd recommed anyone to try this combination in a good set & setting: 15mg 2C-E p.o, wait 1h, take 3g of NaGHB, wait 30min, take 120mg of Ketamine IM.



    And now to my question:

    Does anyone know anything else than these that could prevent tolerance to psychedelics (because I don't really now where to get naloxone ?


    Influence of naloxone on the effects of LSD in monkeys.
    Hadorn DC, Anistranski JA, Connor JD.
    Neuropharmacology. 1984 Nov;23(11):1297-300.

    Three stump-tailed monkeys were trained in an appetitive behavioral task. Administration of 0.1 mg/kg of lysergic acid diethylamide (LSD) moderately disrupted performance acutely, and produced abnormal motor activity. With repeated administration of LSD, motor activity and task responding returned to normal. When 1.0 mg/kg of naloxone was administered prior to administration of LSD in a crossover design, appetitive responding was abolished acutely in all animals and behavior was substantially more disrupted than with LSD alone. Tolerance did not occur with repeated administration of this combination of drugs. Endorphins and/or opiate receptors may act to attenuate the effects of hallucinogenic agents, and may subserve the development of tolerance to these effects.

    PubMed


    Opioid-hallucinogen interactions.
    Domino EF.
    Pharmacol Biochem Behav. 1986 Feb;24(2):401-5.

    Before the advent of neuroleptics, opioids such as morphine were used occasionally in the treatment of schizophrenia and other mental disorders. Recent interest in the possible therapeutic role of endogenous opioid peptides in various mental states has prompted a new look at the opioids. The present paper summarizes the research to date in the author's laboratory on opioid-hallucinogen interactions. A model behavioral state was induced in rats with N,N-dimethyltryptamine (DMT) or lysergic acid diethylamide-25 (LSD). Several mu opioid agonists, antagonists, and synthetic enkephalin analogs interacted with DMT and LSD. Adult male Holtzman rats trained on a positive reinforcement fixed ratio four (FR4) behavioral schedule (i.e., a reward of 0.01 ml sugar-sweetened milk was earned on every fourth bar press) were used in these studies. DMT (3.2 and 10.0 mg/kg) given with a 0.9% NaCl pretreatment IP, disrupted established food rewarded FR4 bar pressing behavior in a dose related fashion. Pre-determined behaviorally ineffective doses of mu opioid agonists showed selective biphasic effects against DMT and LSD. Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects. In contrast to the antagonistic effects of low doses of mu opioid agonists, the mu-kappa opioid antagonist (-)-naloxone enhanced the effects of DMT and LS. (-)-Naloxone enhanced the effects of DMT and LSD. Potentiation of DMT-induced behavioral disruption was attributed to a stereospecific opioid antagonist effect of (-)-naloxone in that the (+)-naloxone enantiomer failed to potentiate the effects of DMT. Further studies are indicated to determine hallucinogen-opioid interactions in various species, including man.(ABSTRACT TRUNCATED AT 250 WORDS)

    PubMed

    ---

    https://rikki.fi/tajkor/bl/does_pind...ychedelics.pdf

    https://rikki.fi/tajkor/bl/naloxone_lsd_monkeys.pdf
     

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    #2
    Bluelighter GABAlover's Avatar
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    I strongly advise you to slow way down. That many drugs used by a person with a history of depression is only going to end badly.
     

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    #3
    Bluelight Crew fastandbulbous's Avatar
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    I've now recently started tripping 4-6 times a week. I think I have some tolerance issues.
    I think you have issues full stop. Tripping every day/every other day is not healthy by any stretch of the imagination and can lead to some very unpleasant states

    Today I have taken 3,5mg of DOC IM and 2mg p.o. Maybe 1g of Ketamine IM (usually 60-120mg at once). 40-60mg of 2C-E. Some Methylone. Some Meth. Some Cocaine. Some GHB.

    It's quite expensive to use that much drugs everyday, but I think that especially psychedelics and ketamine have changed my personality in a very wonderful way. I used to be very depressed, but now life seems like a wonder ride.
    Psychedelics help with psychological problems by having an experience then taking the time to integrate it and relearn previously negative behaviours, not taking them every day like an antidepressant. On top of that you're taking them with other drugs; the ones highlighted are going to make any depression so much worse when you eventually stop. Also if you're taking in excess of a gram of ketamine in conjunction with psychedelics and the highlighted psychostimulants every day, you're asking to be presented with a full on psychotic break that'll land you in a psyche hospital. When thast happens, the meth & coke will stop & you'll get a case of depression that I don't even want to think about.


    Of course you can ignore all this advice, but I'll give it not too long until it all nose dives & you'll be posting on 'The Dark Side' (if you don't get sectioned)
     

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    #4
    Bluelighter almost-'s Avatar
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    I don't normally use psychostimulants at all. Just happened to test some because my friend offered.
     

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    #5
    Bluelighter almost-'s Avatar
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    I don't know but I need ketamine and psychedelics to start my day if I got some things to do. And I need ketamine before going to sleep, it really relaxes me so nicely.
     

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    #6
    What can you do at all during the day if you are on such strong drugs?
     

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    #7
    Bluelighter Trogdor's Avatar
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    What happens if you try to stay sober for a day or two?
     

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    #8
    i would slow the hell down. first of all this is gonna start costing you a fortune. second, as f&b said, you're asking for psychological problems.
     

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    #9
    The tolerance to 5-HT2A agonists (aka psychedelics) can be attenuated by cuncurrent administration of a NMDA antagonist in sub-threshold doses. for example 0.4mg MK-801 orally. The quality of the trip chanages, thoug.
     

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    #10
    Bluelighter almost-'s Avatar
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    Quote Originally Posted by fizzacyst
    What can you do at all during the day if you are on such strong drugs?
    Normal things.
     

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    #11
    Bluelighter almost-'s Avatar
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    Quote Originally Posted by Trogdor
    What happens if you try to stay sober for a day or two?
    These kind of effects:

    Ketamine does not appear to produce withdrawal symptoms in chronic users. (3) There are anecdotal reports of tension, twitchiness, poor attention span, and restlessness in abstinent long term users, but this may be due more to the sedative norketamine (a breakdown product of ketamine) lingering in the blood stream. (4)
    http://www.thegooddrugsguide.com/ketamine/addiction.htm
     

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    #12
    If you want to reduce tolerance, you'll probably need a good week off.
     

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    #13
    Bluelighter Trogdor's Avatar
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    Only a week lol. I'd say that's a tad bit underestimated considering he states he goes about his day normally on these substances.
     

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    #14
    Bluelight Crew fastandbulbous's Avatar
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    Quote Originally Posted by Dr.Heckyll
    The tolerance to 5-HT2A agonists (aka psychedelics) can be attenuated by cuncurrent administration of a NMDA antagonist in sub-threshold doses. for example 0.4mg MK-801 orally. The quality of the trip chanages, thoug.
    I thought that 400ug of MK-801 was well over a threshold dose. I'm sure some reports have reported long lasting noticable activity (generally descriibed as 'not pleasant' at 0.25mg doses). As it appears to last longer than one day as well, isn't there the very real possibility that using 400ug of MK-801 a day (as the OP seems to want to have it for) will have a cumulative effect with increasing levels of MK-801 until it's well past any threshold level?
     

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    #15
    There's a clinical study of MK-801 in patients suffering from ADHD. They administered about 250µg, and the patients did well with it and and particularly women showed good response. There were no cummulative effects, the MK-801 is just too short-lived.
     

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    #16
    Bluelighter almost-'s Avatar
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    Quote Originally Posted by Dr.Heckyll
    There's a clinical study of MK-801 in patients suffering from ADHD. They administered about 250g, and the patients did well with it and and particularly women showed good response. There were no cummulative effects, the MK-801 is just too short-lived.
    Could you send me a copy of that study?
     

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    Human trials of MK-801 
    #17
    Bluelighter almost-'s Avatar
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    Clinical development of dizocilpine (MK 801), the agent with the highest affinity for the ion-channel site and the first drug consistently shown to be neuroprotective in vivo, (18),(46),(47) was abandoned after safety concerns were raised over brain histology changes in rats (see below). A small number of clinical studies were performed in humans, mostly with long-term oral administration. Oral doses as add-on therapy in patients with refractory epilepsy (48) produced minor improvements in seizure activity in a minority of patients and were associated with transient symptoms of agitation (which many epilepsy patients found preferable to the sedating effects of routine anticonvulsants), especially immediately after dose escalation. Oral doses of 0.025 to 0.15 mg/kg were given to adults with attention deficit disorder in an open study of 10 subjects over 6 weeks, (49) with improvement in mood in 5 of 10. Associated symptoms were nonspecific. An open trial in 14 subjects with anxiety disorders (49) was discontinued due to exacerbation of symptoms in the majority. Studies of intravenous dizocilpine in normal volunteers covered a limited dose range and remain unreported.

    Source: Keith W. Muir, MRCP; Kennedy R. Lees, FRCP. Clinical Experience With Excitatory Amino Acid Antagonist Drugs. Stroke. 1995;26:503-513.


    Refs:
    48. Troupin AS, Mendius JR, Cheng F, Risinger MW. MK-801. In: Meldrum BS, Porter RJ, eds. New Anticonvulsant Drugs. London, England: John Libbey; 1986:191-201.

    49. Reimherr FW, Wood DR, Wender PH. The use of MK 801, a novel sympathomimetic, in adults with attention deficit disorder, residual type. Psychopharmacol Bull. 1986;22:237-242.
     

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    #18
    the OP, i believe, is one of the surviving stump-tailed monkeys, mutated post-experiment to master rudimentary writing in order to facilitate the never ending search for the perpetual pleasure principle, aka the joy button.

    now, an image of a monkey on a monkey's back to leave you with.
     

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    #19
    Bluelighter almost-'s Avatar
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    Quote Originally Posted by funks_hybrid
    i would slow the hell down. first of all this is gonna start costing you a fortune. second, as f&b said, you're asking for psychological problems.
    I'm not about to flip out, I'm about to burst into hyperspacelife.

    Just like Dr. Tom:
    https://rikki.fi/tajkor/ELDOCTORTOMAS.htm
    https://rikki.fi/tajkor/TATHOTH.htm
    https://rikki.fi/tajkor/THOTH.htm
    https://rikki.fi/tajkor/THeOTH.htm

    priced and restricted agonists...

    once you have shot or dosed with PURE 1-4 butandiol you will realize your an idot for wasting money and your liver on prescription opiates

    FACT: Mexico sells 50 glas of BASF's best 1 4 Butandiol for $500 USD.. GBL now scheduled here also cures and suppresses CANCER!

    Now are you seeing the Pig picture? AMA DEA BFI CIA=DEATH at all costs.. a bunch of butt fucking pirates who can't admit they like it up the arse:()

    Jesus Fucking ...christ would of killed the hypocrites but why LOVE=POWER:) FOOLS=GOLD:(

    Come on guysz get past the primary chakra:()_

    There in so much more tom sex and space time than an oragsm Terrance McKenna elf in hyperspace

    See Terrance: 50 mg IV 5 Meo DMT 51 sec to go bye pigs are flying;()


    The term "drug" is a confusing term to most public policy makers or end users... I would like to add that almost most drugs that change sensation, change the sexual experiance. I can remember being fucked in the ass while doing free base 5 MeoDMT very sensual and if you control the dose, you just stay on that erotic edge. I can't imagine the poly pharmacy of the ave hard core white party fan over a 10 day period... Proffesional women body builders are like turbo charge teenagers taht will literally fucke you brains out and ask for more.. Intimidating for most guys, but I love em for thier OUT there passion and sex! Hormones are probably the best sex promoting drugs that. 1 -4 Butandiol makes most people porn stars, but is testesterone depandant, this is why men liek it more than pre steroided women. My favorite women array would be: 25 mg methy testosterone 10 IU's r HGH 100mg Trenhbolone acetate 500mg plus (depending on receptor sensitivity to virilization) 2-5 grams 1-4 butandiol 500mg cocaine freebase 20-50mg 5meo 5 DMT freebased or injected 100-200mg MDA 100mgKetamine 2cb 5-20 mg 200mg Silidinafil... Ive seen this amount of drusg done easily in a 24 hour period with your typical 200lb pro female body builder... Of course tehn men like even moe drugs.... It's all about keeping your brain chemistry loaded and centered; TIP: 5 Meo DMT will refresh receptors and be carefull after dosing with post CNS drugs... PHreeX did the 5 Meo DMT about 50mg tripped ahrd then dropped 400mg MDMA dumb ass.... pucked and cried like a babe in my arms... A week or so laetr dropped DOM and wanted to die... years laters totally doped on OXY, lost his sweet rave soul mate and now probably ripping of pharmacies for dope... He at one point wanted surgery to get more oxy.... I tried to help th eBOY but NO one can give you drive and discipline... samrt kid, techy too... I wonder if he is still alive? PLUReally and I give turst for free until you try to fuck me twice:) THOTHme and of course pre and post loading of nueroprotective amnio acids and detxing with 2500mg nicinamide in a wet spa 30 minutes

    Listen to this song very loudly and read at the same time lyrics:
    https://rikki.fi/tajkor/Deicide_-_Sa...%20Suicide.mp3

    Satanized, crucified, feel the wrath of suicide
    Incus fear of the sphere, angel darkness disappears
    Covenant, blasphemous, open up unholiness
    Father Satan, let me just unholy sins

    Suicide sacrifice
    Destruction of holy life
    Blood of unholy knife
    Satan I sacrifice
    Behold the crucifix, symbol of sterility I am crucifix
    Satan Suicide sacrifice, profeasting evil night

    Lust into reality -
    Satan Angel of the black abyss,
    Satan lord I hail
    Insane blasphemous - Satan
    Sacrifical suicide,
    Ritual to end my life
    Behemoth incess my fate - Satan
    Damned to tell, end of my life
    Wrath of God - Satan
    Sin my soul, blesses with fire
    Throne of stone - Satan
    I must die, in my wake
    Seventh gate - Satan
    Suicide, end my life
    I must die - Satan
    Suicide sacrifice, thrust of evil deep inside
    Lucifer never lies, take away thee mortal life
    Demigod, Satan son, commend to body to the ground
    Father Satan, I'll find peace when I am God

    Suicide sacrifice
    Destruction of holy life
    Blood of unholy knife
    Satan I sacrifice
    Behold the crucifix, symbol of sterility I am crucifix
    Satan Suicide sacrifice, profeasting evil night

    TAKE ME!
    Last edited by almost-; 14-11-2006 at 03:38.
     

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    #20
    case in point, i guess. kids, drugs are bad, mkay? BTW, them be some repetitive lyrics, hope your trips are somewhat more interesting.
     

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    #21
    Bluelighter almost-'s Avatar
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    (with 15 mg phosphate ester, orally) "It is meaningful to say that I ceased to exist, becoming immersed in the ground of Being, in Brahman, in God, in 'nothingness,' in Ultimate Reality, or in some similar religious symbol for oneness. The feelings I experienced could best be described as cosmic tenderness, infinite love, penetrating peace, eternal blessing and unconditional acceptance on one hand and, on the other, as unspeakable awe, overflowing joy, primeval humility, inexpressible gratitude and boundless devotion. Yet, all of these words are hopelessly inadequate and can do little more than meekly point toward the genuine, inexpressible feelings actually experienced. It is misleading even to use the words, 'I experienced,' as during the peak of the experience (which must have lasted at least an hour) there was no duality between myself and what I experienced. Rather, I was these feelings, or ceased to be in them and felt no loss at the cessation. Four days after the experience itself, I continue to feel a deep sense of awe and reverence, and am simultaneously intoxicated with an ecstatic joy. This euphoric feeling is in no sense analogous to hebephrenic giddiness; it includes elements of profound peace and steadfastness, surging like a spring from a depth of my being which has rarely, if ever, been tapped prior to the drug experience."
    http://www.erowid.org/library/books_...tihkal16.shtml

    (with perhaps 15 mg, smoked) "I took a hit from the pipe with five-methoxy in it, and after the 8 to 10 seconds it took to carry the chemical to my brain I remember starting to fall over from my sitting position. My normal physical perceptions dissolved away from my awareness. My ears started to ring and I started to float off. I was acutely aware of a certain resonation of my aural perception, an electrical buzzing that fluctuated in synch with my visual perception. What I saw can only be described as a fantastically subtle multicolored phosphene, completely filling every area visually available. I say it in this way because I was simultaneously losing contact with my body, I could not tell if my eyes were open or shut, although I initially had the feeling that they were darting back and forth, from side to side. These feelings and sensations built up in intensity very quickly, a matter of seconds: I can remember this feeling of building intensity up to a point, and then I was not there in my body or in time. In the 10 to 15 minutes that my body was under the influence of the drug my mind was completely referenceless, there was no way for my consciousness to limit or gauge the stimuli my being was barraged with. I remember switching to a perception where the endless and intricate phosphene was love and the energy of light. I called upon those forces within my being to realign and submit, to let go of all the cogent fears and just exist ... and that innate decision saved me a lot of psychic damage. What is most outstanding about the way it feels is an inability to judge in any way, by any method of the mind ... it is unconquerable, as deep and profound as a totally unconditional love that is life. What a trip, huh?"
    http://www.erowid.org/library/books_...tihkal38.shtml
    Last edited by almost-; 14-11-2006 at 03:56.
     

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    #22
    Bluelight Crew fastandbulbous's Avatar
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    GBL now scheduled here also cures and suppresses CANCER!
    If that were the case, don't you think they'd be using it for such? Then again, when you read the rest it sounds like the deranged babbling of someone in desparate need of a giggle jacket...

    Why is it that some people see deranged babbling as enlightenment? Truely enlightened people such as the Dalai Lama don't babble incoherently, but are measured in what they say and come across as thoughtful and very happy in their life, not as some hypomanic loon in full flow.


    case in point, i guess. kids, drugs are bad, mkay?
    I does make it look like that doesn't it
     

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    #23
    Bluelighter almost-'s Avatar
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    I remember when, I remember, I remember when I lost my mind
    There was something so present about that place
    Even your emotions have an echo in so much space

    And when you're out there without care
    I was out of touch
    But it wasn't because I didn't know enough
    I just knew too much

    Does that make me crazy
    Does that make me crazy
    Does that make me crazy
    Possibly

    In all that you were having the time of your life
    But think twice That's my only advice
    Cmon now
    who do you
    who do you
    who do you
    who do you think you are
    ha ha ha
    Bless your soul
    You really think you're in control

    Well
    I think you're crazy
    I think you're crazy
    I think you're crazy
    Just like me

    My heroes had the heart to live their lives out on a limb
    All I remember
    Was thinking I wanna be like them
    Ever since I was little
    Ever since I was little
    It looked like fun
    It was no coincidence I've come
    And I can die when I'm done

    But maybe I'm crazy
    Maybe you're crazy
    Maybe we're crazy
    Probably

    --

    So, we're all crazy or at least maybe, possibly.
    http://www.lyricinterpretations.com/...e33187d552f0f3
     

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    #24
    WTF. You need a break, man.

    either that are you're just starving for attention, and posting random shit to try and get a response.
     

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    #25
    Bro... you need to stop using drugs altogether.
    Recreational ones anyway, at least.
     

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