Thread: Bremelanotide - first true aphrodisiac

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    Bremelanotide - first true aphrodisiac 
    Bluelight Crew phase_dancer's Avatar
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    Mar 2001
    Bremelanotide is being hailed by many as the first true aphrodisiac. Like many well known pharmaceuticals, it was discovered by accident. However, before describing in more detail I thought I'd share another story, one which led me to discover this substance.

    Way back during the eighties when MDMA first appeared locally, I was talking to a friend about it. I'd only known the guy for a year or so, following his return from California with new wife and child. Apart from the odd beer I'd assumed he was straight and always had been. When I mentioned MDMA, he remarked that while in the states he knew a chemist who gave him and his girl a jar of the drug at a time before it became illegal. He then went on to talk about how the guy eventually got busted. My friend said that although they enjoyed their time with the drug, they had certainly had their fill of it.

    Now, for some reason I've always remembered that story. Anyway, a few months ago while attending a party, I bumped into my friend again. It had been nearly 15 years since we'd last seen each other. During conversation I mentioned that story, and he said "Look up Leonard Pickard, he's the guy.... doing 2 life sentences atm..."

    Leonard Pickard; now that name rang a bell, but I couldn't place it. We arrived home late from the party and crashed. I went to sleep with that name in my head, but some 3 hours later I awoke suddenly, remembering where I'd heard it. It was on a piece of video footage shot at the LSD symposium - to also celebrate Albert Hoffman 100th b/day - held earlier this year in Switzerland. I dug out the file and rewatched the piece. It had initially seemed quite confusing although I'd never followed it up.

    Basically, the vid starts with an audience member - blotter-art historian Mark Mc Cloud - as he's interrupting Rick Doblin (from maps) while speaking. Mc Cloud gets quite loud, accussing one of Doblin's cohorts (John Halpern) of cooperating with the DEA to convict Leonard Pickard. The vid then switches to another scene, where surrounded by audience members, Mc Cloud lists the dates that Halpern appeared as witness, implying that Halpern is in part responsible for Pickard getting 2 life sentences for manufacturing LSD. The accusation was that Halpern had testified against Pickard for the DEA so as to gain government funding for MAPS work with MDMA. Pickard and associates had used an abandoned missile silo for manufacturing LSD and were caught with precursor chems and something like 400,000,000 x 100ug doses. So from what I can gather, Pickard was probably fucked anyway.

    Halperngate footage (~32MB)

    I cheked out Leonard Pickard further and was led to The William Leonard Pickard Website where among other very interesting things, the topic of Bremelanotide was addressed.

    So what is this drug? Bremelanotide aka PT-141 was developed by Palatin Technologies. Early tests with Melanotan II, an artificial tanning compound, resulted in male rats developing erections. It was soon discovered the compound responsible was the metabolite of Melanotan II - PT-141, like Melanotan II, it's a cyclic petide. Reports also stated that female rats were so sexually stimulated, that they engaged in the rarely seen behavior where females would mount males.
    It would appear Bremelanotide is fairly free of side effects and is now in stage 3 clinical trials. Depending upon the outcomes, bremelanotide could be available to the public sometime in the near future.

    How does it work? Well, it doesn't work in any way like Viagra or Cialis. Those drugs work by inhibiting a specific phosphodiesterase enzyme which results in increased blood flow to the genitals. This is considered a purely physiological action. Bremelanotide however, seems to work at a much more basic level. It's been described as working on the same brain areas where cocaine and meth cause increased sexual desire. Bremelanotide apparently works in both men and women and is said to work on the same neural areas that are activated when someone gets horny naturally. So it's affects are claimed to be pyschological in essence, resulting in a "natural" state of arousal. However, apart from some claims of youthful euphoria and increased energy, unlike meth and coke, it doesn't result in a high or CNS stimulation.

    The chemical structure of Bremelanotide is somewhat interesting in that it's a peptide containing 8 amino acid residues.

    from Wikipedia: Bremelanotide

    From my digging around I've discovered the drug is available online from chemical suppliers in India and China, although I haven't inquired as to price. Rumours say the Palatin product (their patent) will be very expensive, and that current OS sourced product is not cheap either. This then begs the question of whether the drug could, or will be made in a clandestine environment. Peptide synthesis is not all that difficult if the amino acids and other required chemicals are available (solid phase resins, protecting groups, deprotecting substances, linkers etc). I looked at this subject with great interest while studying drug discovery some years ago. While many of the techniques are different to those employed in most illicit drug syntheses, I do not believe clandestine production is outside the ability of educated chemists (as opposed to back yard cooks).
    It's likely that hydrofluoric acid would be required as deprotecting agent, so if that is the case, clandestine manufacture would be limited to facilities that can protect against accidental exposure (10mg of HF spilt on the skin will kill everytime!)

    Getting back to Pickard's page; Because of the mode of action of this drug, grave concerns have been expressed regarding the possibility of Bremelanotide being used as the next date rape drug. This is certainly a concern, as unlike other drugs used in this manner, Bremelanotide does not result in any noticeable state of intoxication. Also, the dose response window is very large, so many times the standard dose could be administered without apparent side effects. So, while it may be of great benefit to post-menopausal women and men suffering erectile dysfunction, the potential for abuse is certainly there, particularly in the area mentioned.

    From Pickard's Site A Word of Caution Concerning Bremelanotide (PT-141)

    15.) While recognizing that bremelanotide may be effective in ameliorating clearly-defined instances of FSD or ED and may be successfully employed as a marital adjuct, global distribution of an erotogenic drug that selectively induces sexual response may also result in signifiant societal problems, viz.:

    a.) unanticipated social consequences from non-medical use.
    b.) substantially heightened promiscuity across age groups and genders.
    c.) surreptitious administration to unwitting individuals, resulting in drug-induced consensual sexual activity among individuals that would not consent in the absence of the drug.
    d.) a increase in "date-rape" in conjuction with flunitrazepam or other drugs.
    e.) an increase in the incidence of prostitution, including the drug's employment in human trafficking.
    f.) an increase in sexual crimes, including rape, gang-rape, and child abuse.
    g.) uncontrolled use among minors.
    h.) abuse among users of crack cocaine, cocaine, or methamphetamine.
    i.) abuse among populations that would not normally employ any unprescribed drug.
    j.) overdose scenarios requiring medical intervention.
    k.) medical complications from acute or chronic use.
    l.) an increase in sexual aberrrations that are rarely seen by clinicians.
    m.) increased incidence of AIDS and other sexually transmitted diseases.
    n.) increased incidence of unwanted births, and among lower age cohorts.
    o.) the advent of criminal organizations specializing in manufacture or distribution of this or related substances.


    More on PT-141 Is the World Ready for Libido in a Nasal Spray?
    Last edited by phase_dancer; 01-09-2006 at 09:15.

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    Thoughts? Well, for starters, an interesting post as always p_d Other than that, I don't really have any input, but rather, a simple question: Would there be any negative interaction (risk of stroke, etc...) if this drug were to be combined with meth, coke or MDMA to combat the 'shrinkage' effect stimulants tend to produce? It'd be interesting to see or "feel" the synergy of this combination.

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    Bluelight Crew phase_dancer's Avatar
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    I couldn't say. However, I'm sure as time goes on we'll hear if there are contraindications.

    Pharmacologically, as amphetamine and ephedrine possess some of the properties of meth, and SSRI's and other SERT and MAOi drugs are also approved for use worldwide, then any scheduling (approval) of Bremelanotide should mean the drug has been tested for such interactions.

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    Oh man, I want some bremelanotide!

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    Bluelight Crew Fry-d-'s Avatar
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    Cheers for posting that p_d

    Sounds interesting indeed, imagine that as a club drug.....

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    be good to hear some reports on this.
    i have have heard about alot of so called true aphrodisiacs like bromo... mescale can't think of the spelling its like that smart drug hydergina

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    that's big news! never heard of that compound before. i've always wondered about the big gap in the pharmaceutical market when it comes to an aphrodisiac - so many historical potions and modern concoctions, but no drug that actually does the trick, till now.

    there are sure to be some interesting articles published on this drug, especially social implications, something in the same vain as this one on viagra which is an interesting read:

    Bigger and Better: How Pfizer Redefined Erectile Dysfunction

    and being a psychotropic medicine, i'd be heaps curious to read up on what effect it has on people's desires/behaviour/conceptions of sexuality (rather than just their degree of arousal) while they are under the influence....and it's anyone's guess what kind of (if any) broader effects it will have on your noggin-function during/after use.

    as far as i see, the only glaring issue that was missed in the list phase posted from Pickard's site is the potential threat that this drug poses to the survival of the asexual...

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    Quote Originally Posted by Fry-d-
    Sounds interesting indeed, imagine that as a club drug.....
    Nobody would ever go home without sex.

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    Bluelighter tribesman's Avatar
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    Mar 2005
    Wow sounds very interesting. If this does spread as a club drug at some stage however I can see an accompanying increase in the spread of STI's.

    The government add will go alone the line of some straight guy popping the pill and waking up the next morning with two crossdressers with him and AIDS tatooed on his forehead.

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    Bluelight Crew hoptis's Avatar
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    Fascinating stuff. Not the least when you consider a drug like this combined with drugs like Modafinil and you can see the potential for these substances to significantly alter the way people live their lives.

    While the attention of government is more focussed on the moral implications brought on by the advances in genetics and microbiology, the pharmaceuticals are surreptitiously reshaping society into a world where people work all day and have sex all night... sleep and a lack of sexual desire will become things of the past.

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    The pokemon theme is rattling in my brain.... "gotta catch em all"...

    Could you imagine the STD increase if this shit hit the market, in a state of arousal so high, you're hardly likely to reach for a condom even with one on you...all you andthe partner would be thinkin is "ohhh yehh, get that in there"..


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    Wow, this could be a great investment if it passes FDA trials.

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    The Lounge
    Blue_Phlame's Avatar
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    Feb 2005

    Would want some of that right now.

    Good to see there's already an existing thread on this...
    A Phase III clinical trial is scheduled to begin in the first half of 2007.

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    Bluelighter IWillHostIt's Avatar
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    From what I read from another board. It has some shitty side effects.

    Too much hype on this, me thinks.

    Side note: Melanotan I (not 2), will be available first in europe (they started phase 3 trails already). Phase 3 trails have not even began in Australia yet , How bullshit is that. (Available in Australia in 2010 or 2011, long time from now.).
    Last edited by IWillHostIt; 21-04-2007 at 12:37.

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    #15 and yes it does give spontaneous erections too!

    It seems from a cursory glance of the net that Melanotan II is already being used amongst the body building community both for the colour. Side effects of the horniness are well known already on Bodybuilding forums.

    Sounds promising........ Not so sure about the injections though.

    [EDIT: Removed sources. hoptis]
    Last edited by hoptis; 22-04-2007 at 12:11.

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    USA... *sigh*... sux.
    Quote Originally Posted by phase_dancer
    Bremelanotide is being hailed by many as the first true aphrodisiac.
    Crap. Anything that boosts dopamine or inhibits its reuptake works as an aphrodisiac, at varying potencies depending on how much dopamine is increased and/or prevented from being reuptaken.

    Any genuine, powerful aphrodisiac will end up being scheduled by the DEA, period. I guarantee whatever it is will cause fiending/jonesing and cravings, and be highly addictive.

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    Bluelight Crew ocean's Avatar
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    In the shadow of the mountains by the sea
    This is really interesting- I think for some it would be wonderful (if no side effects) But I also agree that it could be very dangerous for it to get into the wrong hands.......It would have to be regulated very carefully- even then im sure it could become a problem. I don't know....Im torn- does the good of it outweigh the bad?

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    Blue_Phlame's Avatar
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    ^ well if you think about it, ANYTHING that gets into the hands of the 'wrong people' has the possibility of becoming a very dangerous problem.

    Only thing we should really worry about is powerful weapons getting into the wrong hands.

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    Bluelighter dbailey11's Avatar
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    Seeing as how I have no girlfriend atm, this would be a horrible idea.....

    *sees self beating off furiously to internet midget porn*
    Last edited by dbailey11; 02-05-2007 at 22:19.

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    Quote Originally Posted by ocean
    This is really interesting- I think for some it would be wonderful (if no side effects) But I also agree that it could be very dangerous for it to get into the wrong hands.......It would have to be regulated very carefully- even then im sure it could become a problem. I don't know....Im torn- does the good of it outweigh the bad?
    Since it needs to be administered intranasally or subcutaneously and is fairly expensive, I doubt that people will have to worry about being dosed up with it against their will. As a peptide, it's also very fragile.

    The side effects are mostly flushing of the face and GI symptoms.

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    Bluelighter IWillHostIt's Avatar
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    ^ What does GI mean?

    nice avatar by the way. that a bomb with a TV in it?, hard to make out. Reminds me of strike.

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    Mostly nausea. Some people get bad headaches, too. It's not scheduled yet, and there a few places selling it online at the moment for about $xxxx/20mg (dose is about 300-600mcg, subcutaneous, last about 12-14 hours).

    It's a bomb that reads "Muhammed" in the center, the same one from that comic that caused the whole silly Muslim burning down embassies fiasco a little while ago (Muhammed is never supposed to be depicted or have is name spoken, despite numerous tapestries depicting him in the 11th and 12th century...).

    [EDIT:No prices or sources. Lil Angel15]

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    hi together,

    i received a vial with 10mg of pt-141

    is this a dose for one person? anyone tried this in combo with mdma?


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    hello dudes,

    sorry cant answer to private messages 'cause i dont have the "bluelighter status"


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    ^ Haha people are already asking for sources

    Wow PD posted this a while ago. Looks like clinically its still a work in progress.

    Cant find any references to dosing. Be carefull

    I wonder if you will have any troubles when you stop taking it, like all everything else.

    Combo with MDMA ? Ha ! Seriously man you will be trying to penetrate the sidewalk.

    Remember to write a trip report. Pay attention to timing it all. Peace.

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