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Thread: Intravenous Nicotine

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    #26
    why not just sample a nicotinic receptor agonist to enable judging as to the potential merits or lack thereof from IV admin?
     

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    #27
    I just read that nicotine from cigarettes that is absorbed through the lungs takes only 10-19 seconds for the drug to reach the brain; faster than an intravenous injection of nicotine.

    Benowitz NL. Nicotine pharmacology and addiction. In: Benowitz NL, editor. Nicotine safety and toxicity. New York (NY): Oxford University Press; 1998. p. 3-16.
     

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    #28
    Bluelighter Intoxo's Avatar
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    I read somewhere that they did a study where they gave IV coke users who smoked shots of coke or nicotine and they couldn't tell the difference.

    I imagine you could chop up a nicotine patch, or open one of those nicotine inhalers, soak it in some water, and try sampling tiny shots of that.
     

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    #29
    Bluelighter Trogdor's Avatar
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    Quote Originally Posted by jasoncrest
    From what I've read, Nicotine seems to be a wonderful substance, with many many good effects, the only downsides are the addictivness and the OD risk...
    But it's nowhere near as dangerous as tobacco, which contains lots of other stuff...
    From wikipedia:
    "The LD50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 4060 mg can be a lethal dosage for adult human beings. This makes it an extremely deadly poison. It is more toxic than many other alkaloids such as cocaine, which has a lethal dose of 1000mg."

    from http://physchem.ox.ac.uk/MSDS/NI/nicotine.html :
    The LD50 for intraveneous administration of nicotine in mice is 0.8 mg/kg.

    What this suggests to me is that IV nicotine administration is 4 times more toxic than oral administration.

    Regardless...


    Nicotine is an extremely deadly poison. Only inject nicotine if you are willing to accept the (very real) risk of accidentally killing yourself.


    *sigh* I posted in another thread that I don't trust any member of the nightshade family. You'd better have a good life insurance policy if you want to try something this stupid.
     

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    #30
    Bluelighter Smyth's Avatar
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    small amounts of nicotine are present in tomatos but i know what u mean.
     

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    #31
    Bluelighter Trogdor's Avatar
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    Almost all of the members of the nightshade family are poisonous. To include anything that has the word 'nightshade' in it, potatoes, tomatoes, tobacco, datura, henbane, etc.
     

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    #32
    Bluelighter jasoncrest's Avatar
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    I bought a Nicotin inhalor, and instead of shooting Bupe with Nicotine, I tried to shoot Bupe, and then huff Nicotine from the inhalator...
    It definitely increases the pleasure, but it doesn't increase the high (anyway I get no high from Bupe); with Nicotine I felt better...

    While it is effective, in my opinion it is not worth the price of Nicotine (being an inhalor, a patch, a gum or a cig....)
     

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    #33
    shoot the shit and then tell us how it went
     

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    #34
    Bluelighter jasoncrest's Avatar
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    Quote Originally Posted by bob123
    shoot the shit and then tell us how it went
    I won't try it, sorry...
    I would be very happy if someone would like to try it for me...

    I experienced the potentiation of Buprenorphine by huffing Nicotine from a Nicotine inhalor (inhalator?) just after shooting Bupe; when doing that, both substances make their effects exactly at the same time...
    So I experienced what I wanted to experiment, no need to try shooting Nicotine, which could be dangerous...

    Anyway:
    -When someone is addicted to Opiates and take his Opiate just to feel normal, but still feel the little pleasure it causes, the pleasure of relief I think, (something linked to Dopamine in the N. Accumbens?); taking Nicotine with his Opiate (smoked while shooting the Opiate or maybe shooting it with the Opiate...), increases this little pleasure, it's not an increased high, just a little pleasure....
     

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    #35
    This thread is wrong on so many levels...
     

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    #36
    I would dissagree with that on many levels...
     

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    #37
    Bluelighter Trogdor's Avatar
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    Quote Originally Posted by bob123
    shoot the shit and then tell us how it went
    sigh. Here how about this, you try that shit and tell us how it went. I'll even help you out by writing your obituary for you.
     

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    #38
    Bluelight Crew 5-HT2's Avatar
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    I want a nicotine inhaler
     

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    #39
    Bluelighter jasoncrest's Avatar
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    Quote Originally Posted by 5-HT2
    I want a nicotine inhaler
    Buy one... It's not that expansive, and very effective...
    Only one huff gives you a strong head buzz...
     

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    #40
    Nicotine is active IV. Dunno that there would be much point to it?

    "...The first modern scientific evidence for this conclusion appeared in the English medical journal Lancet in 1942. Dr. Lennox Johnston there reported that he had given small injections of nicotine solution to 35 volunteers, including himself. "Smokers almost invariably thought the sensation pleasant," Dr. Johnston declared, "and, given an adequate dose, were disinclined to smoke for a time thereafter.... After a course of 80 injections of nicotine, an injection was preferred to a cigarette." If the nicotine injections were abruptly discontinued, craving arose. Dr. Johnston found that in satisfying this craving, one milligram of injected nicotine was roughly the equivalent of smoking one cigarette. He concluded that "smoking tobacco is essentially a means of administering nicotine, just as smoking opium is a means of administering morphine."

    Lennox M. Johnston, "Tobacco Smoking and Nicotine," Lancet, 243 (December 19, 1942): 742.
     

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    IV Nic. 
    #41
    Ex-Bluelighter Helios.'s Avatar
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    Why not?

    Snortable nicotine would likely be more "healthful."
     

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    #42
    Quote Originally Posted by jasoncrest
    Buy one... It's not that expansive, and very effective...
    Only one huff gives you a strong head buzz...
    not if you have tolerance/ addiction.
    I don't want a quitting aid that provides 1/3 the plasma nicotine levels given by a cigarette, I want a cigarette substitute that gives the proper dose as quickly as a cigarette, but I know it would never get licenced.
     

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    #43
    Bluelighter Intoxo's Avatar
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    Just put 2 extra inhalors in your nostrils and breathe deep.
     

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    #44
    Bluelighter adder's Avatar
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    Quote Originally Posted by Helios.
    Why not?

    Snortable nicotine would likely be more "healthful."
    Yeah, it's a deadly poison they say ('4060 mg can be a lethal dosage for adult human beings'). Anyway they don't give a fuck about danger connected with shooting some shit from the street with unknown amount of desired drug.
     

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    #45
    Quote Originally Posted by Intoxo
    Just put 2 extra inhalors in your nostrils and breathe deep.
    doesn't work, tried smoking inhalors too, but they don't stay lit and the plastic smells like DMT - nasty

    more seriously 'ad libitum dosing' ie as much as you want when you want only results in peak plasma levels 1/3 that of a cigarette, its a case of partly how much but also how fast its delivered for the desirable effects. slow administration of large dose = unpleasant
    fast adminsitration of low dose = OK
    fast administration of reasonable dose= whats wanted

    seems that the cigarette produces finely divided nicotine and vapour in the right size for rapid max absorbtion
     

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    #46
    Why not dissolve a nicotine 'Microtab' in water, filter off the insoluble binders, allow the water to evaporate and then vaporise the nicotine residue in the same way as you would do with MJ?
     

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    #47
    Bluelighter jasoncrest's Avatar
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    Quote Originally Posted by Electrolyte
    Why not dissolve a nicotine 'Microtab' in water, filter off the insoluble binders, allow the water to evaporate and then vaporise the nicotine residue in the same way as you would do with MJ?
    Because it would be a lot of work, and not worth it, as inhalators exists...
    Each capsule you put in the inhalator contains 10mg Nicotine, that's much more than a regular cigarette...
     

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    #48
    Yes, but using the method I suggested would result in a greater rate of absorption and therefore would theoretically be more pleasurable. The nicotine from inhalators is in fact absorbed through the mucous membranes in the mouth rather than the lungs.

    Correct me if I'm wrong, but I think the only reason inhalators are used is because people become addicted to the act of smoking itself (like a needle fixation) and using an inhalator simulates the smoking of a cigarette.
    Last edited by Electrolyte; 18-08-2006 at 22:30.
     

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    #49
    Ex-Bluelighter Helios.'s Avatar
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    LD50 500mg/person po.
     

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    #50
    4060 mg can be a lethal dosage for adult human beings.
    wikipedia
    that's a pack of cigarettes. Be careful or just don't attempt it.

    But what was said about nicotine absorbtion in cigarettes is true.. most major brands altered the pH to make it more basic and vaporize faster, giving cigarettes a fast rush.. It's safer in the moment and probably faster than injection. The corporations have you beat there already!
     

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